Janja Marc
University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia

2.1 Introduction

The first recognition of clustering of hypertension, hyperglycemia and gout came already in twenties of 20th century . In 1988 Reaven identified Syndrome X originating from insulin resistance (IR). In 2004 The National Cholesterol Education Program's Adult Treatment Panel III (ATPIII) defined the metabolic syndrome with alternative names: IR syndrome, Reaven syndrome, characterized by following components:

� insulin resistance
� abdominal obesity
� atherogenic dyslipidemia and cardiovascular disease
� hypertension
� proinfammatory state
� prothrombotic state

Read more