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Grazyna Sypniewska
Department of Laboratory Medicine, Collegium Medicum, Nicolae
Copernicus University, Bydgoszcz, Poland
The metabolic syndrome represents
combined occurence of atherogenic dyslipidemia, insulin resistance,
elevated blood pressure and central adiposity. Pro-inflammatory and
prothrombotic state contributing to endothelial dysfunction is a
common feature of those with metabolic syndrome. Increasing
frequency of abdominal obesity, reaching epidemic proportions,
enhances the prevalence of metabolic syndrome. Both, obesity and
metabolic syndrome, have the potential to influence on the
incidence and severity of cardiovascular disease with serious
implications for worldwide health care systems.
Visceral obesity is a key component
in the development of the metabolic syndrome. Increased central
adiposity, particularly in visceral region, leads to greater free
fatty acid flux and inhibition of insulin action. Adipose tissue in
obesity is resistant to insulin which is associated with
disturbed glucose metabolism in the muscles and liver. Even mild or
moderate degree of obesity with concomitant insulin resistance may
be associated with metabolic syndrome. On the other hand, excessive
accumulation of abdominal fat may lead to the development of
metabolic syndrome independently on degree of insulin
resistance.
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