Project number 2001-059-1-700:
PROPERTIES AND UNITS FOR TRANSFUSION MEDICINE AND IMMUNOHAEMATOLOGY (Technical report) (IFCC-IUPAC 2003)
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Prepared for publication by
- Dept. Clin. Immunology, Aalborg University Hospital, Aalborg, Denmark
- Div. Clin. Microbiology, Link�ping University, Link�ping, Sweden
- The National Board of Health , Copenhagen S, Denmark
#The combined Membership of the IFCC Committee during the preparation of this report (2001- 2002) was as follows:
Chairman: U. Forsum (Sweden). Members: P. Soares de Araujo (Brazil; 1994- ); R. Dybk�r (Denmark; 1996- ); A. Jabor (Czech Republic; 1998- ); W. R. K�lpmann (Germany; 1998- ); G. Nordin (Sweden; 2000-
�The combined Memberships of the Task Group during the preparation of this report (2001-2002) was as follows:
Chairman: U. Forsum (Sweden). Members: P. Soares de Araujo (Brazil); R. Dybk�r (Denmark); A. Jabor (Czech Republic); G. Nordin (Sweden) and W. K�lpmann (Germany)
Please forward comments to:
K. Varming, Dept. Clin. Immunology, Aalborg University Hospital, Postbox 561, DK-9100 Aalborg, Denmark; e-mail: firstname.lastname@example.org
--> Full List of Terms Here <--
This document is part of an ongoing effort to standardize transmission of laboratory data across cultural and linguistic domains, without attempting to standardize the routine language used by clinicians and laboratory practitioners.
It comprises a general introduction, and an alphabetic list of properties. The list is based on the syntax for properties recommended by the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) and the International Union of Pure and Applied Chemistry (IUPAC) . The nomenclature is primarily from the Working Party on Terminology of the International Society of Blood Transfusion (ISBT) [2-5].
The purpose of this document is to create a systematic terminology, that can be used as the basis for encoding laboratory messages in the domain of transfusion medicine and immunohaematology. The systematic terms and unique codes for properties recommended for scientific communication and in requests and reports are primarily for the purpose of unambiguous data exchange. Their use by clinicians or laboratory practitioners is optional but encouraged.
Syntax and definitions
syntax: System(specification)�Component(specification); kind-of-property(specification) = (x).(x) .
EXAMPLES: NPU21943 Neutrophilocytes(Blood)�Immunoglobulin A; arbitrary entitic number(procedure) = ? arbitrary unit
NPU01945 Erythrocytes(Blood)�Erythrocyte antigen; taxon(AB0; RhD; procedure) = ?
system: demarcated arrangement of a set of elements and a set of relationships between these elements 
EXAMPLE: a portion of blood, a portion of plasma, a portion of erythrocytes.
component:definable part of a system 
EXAMPLE: Erythrocyte A antibody as part of a plasma sample.
kind of property: attribute of phenomena, bodies or substances that may be distinguished qualitatively
NOTE 1 - In ENV 1614 the term property (in a general sense) is used as synonym for kind-of-property.
NOTE 2 - A kind of property may be qualified by each user to nominal scale, ordinal scale, difference scale or ratio scale. The last three types of kind-of-property are also called kind-of-quantity.
compatibility :mutual tolerance
NOTE 1 - There is presently no officially approved definition. The definition for this kind-of-property is for use in this document only.
EXAMPLE: NPU21410 Plasma B-lymphocyte antibody; compatibility(donationID; absent present) = ?
nominal scale:scale with a set of possible values for a given kind-of-property that are each a word or symbol without any relation to magnitude 
EXAMPLE: taxon of erythrocyte antigen in a sample of blood identified as BARC; Cra.
NOTE - The values may be listed in any order according to practical considerations and convention.
ordinal scale:scale with an ordered set of possible values for a given kind-of-quantity that are each a word or symbol used for ranking according to magnitude, but where differences or ratios between values have no arithmetic meaning 
EXAMPLE: arbitrary number of Immunoglobulin M molecules(median) per erythrocyte in a sample of blood found as �0� or �1�; or �absent� or �present�; or �negative� or �positive�.
ratio scale:scale of measurement with an ordered set of values for a given kind of measurable quantity that are each a product of numerical value and unit of measurement such that a given ratio between values corresponds to the ratio between magnitudes of the measurable quantities along the scale 
EXAMPLE: entitic number of immunoglobulin A molecules(median) per thrombocyte in a sample of thrombocytes.
list of related properties: some requests elicit a series of related properties that may be grouped under a common heading in a report. The heading is for requesting and the list of properties presented is for selection by the individual laboratory
EXAMPLE: NPU21970 P�HNA antibody(IgM); arb.c.(list; 0 1)
NPU21971 P�HNA-1a antibody(IgM); arb.c. = 0
NPU21972 P�HNA-1b antibody(IgM); arb.c. = 0
NPU21973 P�HNA-1c antibody(IgM); arb.c. = 0
NPU21974 P�HNA-2a antibody(IgM); arb.c. = 1
NPU21975 P�HNA-3a antibody(IgM); arb.c. = 0
NPU21976 P�HNA-4a antibody(IgM); arb.c. = 0
NPU21977 P�HNA-5a antibody(IgM); arb.c. = 0
Alternatively the request and report in these cases may be reduced to a single entry using the kind-of-property taxon and nominal results if the actual list of properties looked for in the procedure is part of the general information from the laboratory.
EXAMPLE: NPU21924 P�HNA antibody(IgM); taxon = HNA-2a
designation of property:set of data elements comprising information on system, component and kind-of-property and their adherent specifications.
NOTE 1 - There is presently no officially approved definition. This definition is for use in this document only.
NOTE 2 - Information about identification of system, time and result is not considered in the entries of this document.
EXAMPLE: Lymphocytes(Blood)�B-lymphocytes(immature); number fraction.
International Coding Scheme Identifier, ICSI: identifier assigned to uniquely identify a registered coding scheme for use in information interchange 
EXAMPLE: �NPU� for codes allocated by the C-NPU of the IFCC-IUPAC.
code value :result of applying a coding scheme to an element in a coded set 
EXAMPLE of number and term: 21406 for Blood�Crossmatch(electronic); expiry(date and hour; procedure)�.
Systematic Request and Report of Clinical Laboratory Results
The parts comprised in the concept of �term of property� and in the concept of �term of a result� are presented in table 1.
|Table 1. Systematic request and report
Identification and time
object or patient identification
date and time(s) of sampling
|Equality, inequality or other operator
|value (for quantities on a difference or ratio scale, a numerical value multiplied by a unit; the unit �one� is omitted)
By convention, properties and results of examinations are connected through an operator.
- Parts 1 and 2 are Essential for a request; that is information on patient identification, time or time interval for sampling, and information on the property requested.
- The laboratory report on a particular property comprises the three parts 1, 2 and 3.
- To each element in part 2 may be added a specification as a parenthetic suffix for clarification and to avoid ambiguity.
- Note(s) (part 4) relating to, for example, diagnosis, medication, haemolysis or hardware breakdown are not included, except when needed for the interpretation of results such as pretreatment of patient or subject.
- Thus the elements of a term for a type of property comprise: System(specification)�Component(specification); kind-of-property(specification in the form of procedural details).
- This is as recommended by IFCC and IUPAC  and by the European standard ENV 1614:1995 .
- EXAMPLE: Erythrocytes(Blood)� Erythrocyte antigen; taxon(AB0; RhD; procedure).
- The elements of a result comprise: an operator (= < > etc.), a numerical value and any unit or name, usually in symbolic form. This is as recommended by the European standard ENV 12435:1996 .
- Nominal and ordinal scale values carry no unit. In difference and ratio scales the unit must never be omitted in reporting results, except for the unit 1.
- It is further recommended that the result includes or refers to a value for a measure of uncertainty .
- The names of components are primarily from the Working Party of the International Society of Blood Transfusion [2, 3, 4, 5].
- In addition to the systematic term of the property, an example is given in abbreviated format..
For details, see IUPAC�IFCC (Recommendations 1995). Syntax and semantic rules .
Elements of an Entry
The terms recommended are given in bold, that is: the systematic term for the type of property, the unit and the code value.
- Name of system and parenthetic specification spelled out in full, and followed by a long dash (em dash)
- Alphanumeric chemical prefixes to component name
- Recommended name of component and parenthetic specification Shifted to the left for alphabetical sorting and searching, and followed by a semicolon
- Kind-of-property and parenthetic specification
- Molar mass (M) for conversion from other units
- Presently recommended calibrator
- Previous calibrator(s)
- Other term(s)
- Authority: Code value for the international organisation recommending the name of the component or the combined elements of an entry
- Note with any further information
- [NPUXXXXX]. Code value, intended for interlaboratory transmission between databases
- Example in abbreviated form
The term �arbitrary� in principle cannot be related to a volume. In clinical chemistry, however, a less well defined �in-house� or a regional calibrator is often referred to and is expressed in �arbitrary unit per litre� in order to enable comparison of patient data over time and regionally. In each of these instances further information should be given in the parenthesis �procedure�
In the examples given, a question mark, �?�, has been used to represent the value of a result for properties including quantities.
- Complement + Immunoglobulin;
- arbitrary entitic number(procedure)
- arbitrary unit
- Other term(s): Coombs test
- Ercs(B)�Complement + Immunoglobulin; arb.entitic num. = ? arb.unit
- IUPAC�IFCC (International Union of Pure and Applied Chemistry�International Federation of Clinical Chemistry), Commission/Committee on Quantities and Units (in Clinical Chemistry), 1995. Compendium of terminology and nomenclature of properties in clinical laboratory sciences. The Silver Book. JC Rigg, SS Brown, R Dybkaer, H Olesen. Oxford: Blackwell Science, 290 pp.
- ISBT Working Party on Terminology for Red Cell Surface Antigens. Terminology for red cell surface antigens. Blood group terminology. Prepared for publication by Geoff Daniels September 2000. http://www.iccbba.com/wpantigentables.htm
- ISBT Working Party on Platelet and Granulocyte Serology, Granulocyte Antigen Working Party. Nomenclature of Granulocyte Alloantigens. Prepared for publication by J Bux. Vox Sang.. 1999; 77:251
- International Society for Thrombosis and Haemostasis(ISTH) and International Society of Blood Transfusion (ISBT). Human Platelet Alloantigens (HPA). Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University Giessen, Germany 20 November 2002 http://www.med.uni-giessen.de/immunologie/Forschungsschwerpunkte.htm
- The Anthony Nolan Trust. HLA Informatics Group. 19 July 2002 http://www.anthonynolan.org.uk/HIG/nomenc.html
- CEN/TC 251,1995. European Prestandard ENV 1614. Medical informatics. Structure for nomenclature, classification and coding of properties in clinical laboratory sciences
- International Organization for Standardization. International Standard ISO/IEC7826-1:1994 Information technology � General structure for the interchange of code values � Part 1: Identification of coding schemes
- CEN/TC 251, 1996. European Prestandard ENV 12435:1996. Medical Informatics. Expression of the results of measurement in health sciences
- Syntax and semantic rules. Prepared for publication by H Olesen. Pure Appl. Chem. 1995; 67: 1563-74; Eur. J. Clin. Chem. Clin. Biochem. 1995; 33: 627-36; Clin. Chim. Acta 1996; 245: S5-S21.
Index of Abbreviations
C-NPU Commission on Nomenclature, Properties and Units
IFCC International Federation of Clinical Chemistry and Laboratory Medicine
ISBT International Society of Blood Transfusion
IUPAC International Union of Pure and Applied Chemistry
Copyright © 2004 International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). All rights reserved.