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Vol 18 n° 1

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eJIFCC 2007,18 (1) Genetic Succeptibility to Metabolic Syndrome

Janja Marc
University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia

 

2.1 Introduction


The first recognition of clustering of hypertension, hyperglycemia and gout came already in twenties of 20th century . In 1988 Reaven identified Syndrome X originating from insulin resistance (IR). In 2004 The National Cholesterol Education Program's Adult Treatment Panel III (ATPIII) defined the metabolic syndrome with alternative names: IR syndrome, Reaven syndrome, characterized by following components:

� insulin resistance
� abdominal obesity
� atherogenic dyslipidemia and cardiovascular disease
� hypertension
� proinfammatory state
� prothrombotic state

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