University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia
The first recognition of clustering of hypertension, hyperglycemia and gout came already in twenties of 20th century . In 1988 Reaven identified Syndrome X originating from insulin resistance (IR). In 2004 The National Cholesterol Education Program's Adult Treatment Panel III (ATPIII) defined the metabolic syndrome with alternative names: IR syndrome, Reaven syndrome, characterized by following components:
� insulin resistance
� abdominal obesity
� atherogenic dyslipidemia and cardiovascular disease
� proinfammatory state
� prothrombotic state
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