Advancing excellence in laboratory medicine for better healthcare worldwide

Vol 18 n° 3

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Neonatal screening programme for increasing early postnatal diagnosis of congenital cytomegalovirus infection in the West Poland Province


Malgorzata Paul1*, Jerzy Szczapa2, Irena Wojsyk-Banaszak2, Anna Jaworska2, Jerzy Stefaniak1

1 Department and Clinic of Tropical and Parasitic Diseases, University of Medical Sciences, Poznan, Poland
2 Clinic of Neonatal Infectious Diseases, Department of Neonatology, University of Medical Sciences, Poznan, Poland

SUMMARY
Congenital infection with cytomegalovirus (CMV) is the main cause of sensorineural hearing loss and psychomotor impairment which can develop at birth or later in infant's life. Because of a lack of nation-wide serological screening for pregnant women and accepted antiviral therapy during pregnancy in a high seroprevalence rate population of Poland, we introduced the regional screening programme for CMV infection in neonates from the Poznan Province to diminish a risk of the symptomatic disease. The aims of the study were: (i) to determine the prevalence of specific anti-CMV antibodies in populations of pregnant women and newborns from the Poznan area, (ii) to increase the early postnatal detection of congenital CMV infections, and  (iii) to evaluate a risk of perinatal or early postnatal infections with CMV in newborns or infants born to seropositive mothers. Serological testing was performed in 4.192 live born neonates, using dried blood filter-paper specimens.

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