Advancing excellence in laboratory medicine for better healthcare worldwide

Vol 18 n° 3

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Serological screening of newborns for Toxoplasma gondii-specific IgA and IgM


Malgorzata Paul

Department and Clinic of Tropical and Parasitic Diseases
University of Medical Sciences, Poznan, Poland

SUMMARY
The strategic approach for preventing congenital toxoplasmosis is strictly related to the incidence of primary T. gondii infection during pregnancy in a studied population. Early postnatal diagnosis by mass testing of newborns is an option in areas where obligatory serological screening in pregnant women has not been implemented but it requires sensitive immunodiagnostic methods followed by a good confirmatory analysis. The aims of the regional neonatal screening programme were (i) analysis of the prevalence of congenital T. gondii infection at birth in the West Poland Province, (ii) determination of the value of the serological examination of filter-paper blood specimens collected at birth for the diagnosis of congenital toxoplasmosis, and (iii) evaluation of the duration of T. gondii-specific immunoglobulin A and immunoglobulin M antibodies in infants'sera.

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