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IOF-IFCC study

Published: Thursday, March 6, 2014

The current study follows a position paper published in 2011 by the IOF-IFCC Bone Marker Standards Working Group recommending the use of bone formation marker serum s-PINP and bone resorption marker serum s-CTX as reference markers to be used in future studies of fracture risk assessment.

In the study, ten potentially eligible publications were identified and six included in the meta-analysis. The results showed a moderate but significant association between the bone turnover markers studied and the risk of future fractures not adjusted for bone mineral density (BMD). There was a significant association between s-PINP and the risk of fracture.

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