Advancing excellence in laboratory medicine for better healthcare worldwide

Harmonisation of Autoantibody Tests (WG-HAT)



Name Position Country Term Time in Office
J. Sheldon Chair UK 2nd 2013 01 - 2015 12
P.L. Meroni Member IT
I. Zegers Member BE

Terms of Reference

  • To evaluate what are the main causes of variability for a number of diagnostically critical autoantibody measurements.
  • To identify autoantibodies where a common calibrator could reduce the inter-assay variability
  • To identify or produce commutable reference materials that could be used as interim calibration material for autoantibody assays.
  • To produce well-characterised pure antibody preparations with known concentration and identity and use these to transfer values to a matrix preparation.

Current projects

  • Evaluation of EQA data to identify the autoantibody tests with the potential for harmonisation of results.
  • Gathering a comprehensive data base of the assay characteristics of the currently available autoimmune serology methods.
  • Identifying existing materials that could be used to assess interassay variability and possibly be used as interim calibration material.
  • Defining the requirements for a calibration material for autoimmune serology.


List of Corresponding Members, nominated by National Societies

Name Full and Affiliate Member Societies
David Gillis Australasian Association of Clinical Biochemists
Xavier Bossouit Société Belge de Chimie Clinique (SBCC)
Pierre Carayon Société Française de Biologie Clinique (SFBC)
Rudolf Gruber Deutsche Vereinte Gesellschaft für Klinische Chemie und Laboratoriumsmedizin e.V. (DGKL)
Tímea Berki Hungarian Society of Laboratory Medicine (MLDT)
Naoya Inoue Japan Society of Clinical Chemistry (JSCC)
Loreta Bagdonaite Lithuanian Society of Laboratory Medicine
Gabriel Oyeyinka Association of Clinical Chemists Nigeria (ACCN)
Neslihan Bukan Turkish Biochemical Society (TBS)


List of Corresponding Members, nominated by Corporate Members

Name Corporate members
Michael Rottmann ROCHE Diagnostics GmbH

Working Group Chair's contact

Dr. Joanna SHELDON
Protein Reference unit
St. George's Hospital
Blackshaw Road
London SW17 0NH
Te.: +44 (0) 208 725 5752
Fax: +44 (0) 208 725 0025

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