Advancing excellence in laboratory medicine for better healthcare worldwide

Standardization of Bone Markers Assays (WG-BMA)

Membership

Name Position Country Term Time in Office
H. Morris Chair AU 2nd 2015 01 - 2017 12
C. Cooper Co Chair - International Osteoporosis Foundation
S. Vasikaran Secretary AU
C. Biegelmayer Member AT
E. Cavalier Member BE
EF. Eriksen Member NO
A. Griesmacher Member AT
K. Makris Member GR
S. Niemi Member
J. Kanis Member/IOF
M. Munk Corp. Rep/IDS
B. Ofenloch Haehnle Corp. Rep./Roche
S. Silverman National Bone Health Alliance (NBHA)

Terms of Reference

  • To standardize or harmonize (as technically feasible or appropriate at this time) clinical assays available for routine and research use, for the following two bone turnover markers; the serum assay for C-telopeptide fragments of collagen type I a1 chains containing the epitope Glu-Lys-Ala-His-Asp-ß-Gly-Gly-Arg in an isomerised form (also known as serum Crosslaps (CTx)) and the serum assay for N-terminal Propeptide of Type I Procollagen (P1NP).

Current Projects

  • Review literature and current status of available assays in order to develop and undertake a project to establish a reference measurement system for serum β-CTx or harmonisation of the assays for serum β-CTx as appropriate.

  • Review literature and current status of available assays in order to develop and undertake a project to establish a reference measurement system for serum P1NP or harmonisation of the assays for serum P1NP as appropriate.

  • Review and identify data required for the regulatory authorisation of these modified assays.

  • Review literature and consider the critical decision limits and potential target levels of serum β-CTx and serum P1NP for treatment of postmenopausal osteoporosis and other causes of osteoporosis as appropriate

 

IOF-IFCC study summarizes fracture prediction strength of reference bone turnover markers 

 

List of Corresponding Members, nominated by National Societies

Name Full and Affiliate Member Societies
Masakazu Miura Japan Society of Clinical Chemistry (JSCC)
Elaine Azinge Association of Clinical Chemists Nigeria (ACCN)
Aylin Sepici Dincel Turkish Biochemical Society (TBS)

 

List of Corresponding Members, nominated by Corporate Members

Name Corporate members
Neil Parker SIEMENS 

Working Group Chairs'  contact

Prof. Howard MORRIS
Chemical Pathology Directorate, SA Pathology
BOX 14 Rundle Mall Post Office
Adelaide
Australia 5000
Tel.: +61 423780759
Fax: +61 8 8222 3518
E-mail: Howard.Morris@health.sa.gov.au

 
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