Standardization of Bone Markers Assays (WG-BMA) in collaboration with IOF
||Time in Office
||2018 01 - 2020 12
||Co Chair - International Osteoporosis Foundation
|B. Ofenloch Haehnle
||National Bone Health Alliance (NBHA)
Terms of Reference
To standardize or harmonize (as technically feasible or appropriate at this time) clinical assays available for routine and research use, for the following two bone turnover markers; the serum assay for C-telopeptide fragments of collagen type I a1 chains containing the epitope Glu-Lys-Ala-His-Asp-ß-Gly-Gly-Arg in an isomerised form (also known as serum Crosslaps (CTx)) and the serum assay for N-terminal Propeptide of Type I Procollagen (P1NP).
- Review literature and current status of available assays in order to develop and undertake a project to establish a reference measurement system for serum β-CTx or harmonisation of the assays for serum β-CTx as appropriate.
- Review literature and current status of available assays in order to develop and undertake a project to establish a reference measurement system for serum P1NP or harmonisation of the assays for serum P1NP as appropriate.
- Review and identify data required for the regulatory authorisation of these modified assays.
- Review literature and consider the critical decision limits and potential target levels of serum β-CTx and serum P1NP for treatment of postmenopausal osteoporosis and other causes of osteoporosis as appropriate
- IOF-IFCC study summarizes fracture prediction strength of reference bone turnover markers
List of Corresponding Members, nominated by National Societies
||Full and Affiliate Member Societies
||Japan Society of Clinical Chemistry (JSCC)
||Association of Clinical Chemists Nigeria (ACCN)
|Aylin Sepici Dincel
||Turkish Biochemical Society (TBS)
List of Corresponding Members, nominated by Corporate Members
Working Group Chairs' contact
Prof Etienne Cavalier, PhD, EuSpLM
Head, Department of Clinical Chemistry
University of Liège, CHU de Liège
Route 52, Porte 53
Domaine du Sart-Tilman
B-4000 Liège, Belgium
Tel: +32 4 366 88 22 or 76 92
Fax:+32 4 366 88 23