Advancing excellence in laboratory medicine for better healthcare worldwide

Committee on Clinical Applications of Cardiac Bio-Markers (C-CB)

IFCC Webinar on:

Analytical and Clinical Aspects of Natriuretic Peptides

This webinar, organized by the C-CB, addresses educational issues pertaining to natriuretic peptide (NP) assays and their role in laboratory medicine and clinical practice. Presentations  addresses the differential diagnosis of increased NPs, review the appropriate indications for utilization of NPs for ruling in and ruling out heart failure and in assessing therapy and risk outcomes. Guideline and recommended medical decision thresholds will be addressed for appropriate NP assays use, along with educating audience on what BNP and NT-proBNP assays are measuring in health and disease.

Specifically, Drs Saenger and Kavsak will focus on the AACC and IFCC guidelines and recommendations pertaining to the analytical roles of the numerous BNP and NT-proBNP assays to better understand what forms of natriuretic peptides and their degradation products are being measured in acute and chronic heart failure patients. Further, they will address appropriate cutoff concentrations and how they should be determined for use in clinical practice. Prof. Lam with review how the similarities and potential differences for how BNP and NT-proBNP assays are used in clinical practice, along with international heart failure association practice guidelines and recommendations.

This webinar comprises of three following presentations of 20 min each, followed by 20 min of panel discussion at the end where the speakers will answer to your questions.
Chair/Moderator: Prof. Jordi Ordonez-Llanos
Talk 1: " Natriuretic Peptides: Laboratory & Assay Analytics Part 1" – Dr. Amy Saenger
Talk 2. " Natriuretic Peptides: Laboratory & Assay Analytics Part 2" – Dr. Peter Kavsak
Talk 3: " Clinical Utilization of Natriuretic Peptides in Heart Failure" - Prof. Carolyn S.P. Lam


IFCC Webinar on:

High-Sensitivity Cardiac Troponin Assays - Clinical Applications

This webinar, organized by the C-CB, addresses educational issues pertaining to high-sensitivity cardiac troponin I & T assays and their role in clinical practice. Evidence-based educational information addresses their utilization for the detection and management of myocardial injury, early rule out of myocardial infarction in the emergency department, and diagnostics and risk assessment and stratification in patients presenting with symptoms suggestive of ischemia. Current guidelines and recommendations are presented and appraised.

 

Specifically, Professor Jaffe  elaborates on the non-ACS myocardial injury patients, Professor Omland on the role of hs-cTn assays in the diagnosis of type 1 and type 2 MIs as well as address baseline concentration pertaining to risk stratification and short and long term outcome assessment, while Professor Body  focuses on both baseline and 0/1h and 0/2 h rule out pathways to better manage and triage patients presenting with symptoms suggestive of MI.

 

This webinar comprises of three following presentations of 20 min each, followed by 20 min of panel discussion at the end where the speakers will answer to your questions.

 

Chair/Moderator: Prof. Fred Apple

Talk 1: "Myocardial Injury" - Prof. Allan Jaffe 

Talk 2. " Early Rule Protocols" - Prof. Richard Body

Talk 3: " Diagnosis and Risk Assessment" - Prof. Torbjørn Omland


IFCC Webinar on:

This webinar, organized by the C-CB,  addresses educational issues pertaining to high-sensitivity cardiac troponin I & T assays and the clinical laboratory’s role in patient care addressing assay imprecision, interferences and implementation, including point of care assays. We  provides evidence-based information that laboratory professionals will be able to use to education their clinical colleagues for optimal interpretation of cTn measurements. Professor Apple will both moderate the session, as well as discuss the recent advances of whole blood POC hs-cTn assay. Professor Collinson will discuss the challenges related to real world practice in consideration of establishing hs-POC testing in parallel or combination with central laboratory testing. Dr. Aakre will address how imprecision of hs-cTn assays may affect patient classifications in early rule out strategies used in the emergency department. Professor Hammarsten will educate the audience on the latest developments of macro-troponin interferences that can be quite variable between hs-cTn assays, and explain how this interference concerns clinicians with interpretation during patient care.

 

This webinar comprises of three following presentations of 20 min each, followed by 20 min of panel discussion at the end where the speakers will answer to your questions.

 

Chair/Moderator: Prof. Fred Apple
Talk 1: "Challenges for Implementation" - Prof. Paul Collinson
Talk 2. " Analytical Performance of Assays and Effects on Algorithms Used in the Emergency Department" - Dr. Kristin Moberg Aakre
Talk 3: " Assay Interferences - Macro-Troponin" - Prof. Ola Hammarsten


IFCC Webinar on:

"C-CB Appraisal of 2020 ESC Guidelines for the Management of Acute Coronary Syndromes in Patients Presenting Without Persistent ST-Segment Elevation: Getting Cardiac Troponin Right"

Essentially all activities in the clinical laboratory carry with them the risk, some have greater potential for harm to patients and clients to various laboratory services. Maintaining a robust, safe, and high-quality laboratory service requires an acknowledgment of these risks and responding to this by embedding processes to measure and identify, analyze, and implement corrective actions to reduce frequency and impacts of risks, and/or provide warning systems to alert to situations where there is increased potential.

In this session, we provide an overview of risk management in healthcare focusing on clinical laboratories. We discuss the relationship of risk management to standards for best practice.
The presentations provide an explanation of explain how risk management is done and highlight risk management frameworks like Failure Modes and Effects Analysis (FMEA), Root Cause Analysis (RCA), and others. We finally explore how risk management strategies are used in continuous improvement initiatives, and other projects bringing about change to the laboratory work environment and its processes.

 

Membership

NamePositionCountryTermTime in Office
F. AppleChairUS2nd2020 01 - 2022 12
P. KavsakMemberCA2nd2020 01 - 2022 12
O. HammarstenMemberSE1st2020 01 -2022 12
A. SaengerMemberUS2nd2020 01 - 2022 12
R. BodyMemberUK2nd2020 01 - 2022 12
N. MillsMemberUK1st2022 03 - 2024 12
K. Moberg AakreMemberNO1st2021 01 - 2023 12
P. CollinsonConsultantUK
A. JaffeConsultantUS
J. Ordoñez-LlanosConsultantES
T. OmlandConsultantNO

Terms of Reference

  • Education; Established and novel cardiac biomarkers
  • Biochemistry of cardiac biomarkers
  • Clinical use of cardiac biomarkers: risk stratification, diagnostics, therapy
  • Laboratory issues on cardiac biomarkers: 99th percentiles, delta values, biological variation, quality specifications of assays

Click here to see the list of the C-CB Published Manuscripts

Current Projects

  • Development of educational materials about high-sensitivity, contemporary and point of care cardiac troponin assay use in clinical practice.
  • Development of educational materials about natriuretic peptide assay use in clinical practice
  • Development of educational expert opinion materials in collaboration with The Academy of the AACC on the use of cardiac troponin in coronary disease
  • Updating cardiac troponin and natriuretic peptide assay tables by both manufacturer claims and from peer-reviewed literature
  • Distribution of educational posters and mouse-pads addressing high sensitivity cardiac troponin assays at IFCC meetings in 2017 and in 2018.
  • Distribution of flash keys at AACC 2019.

11 May 2022

On behalf of the members of the IFCC Committee on Clinical Applications of Cardiac Bio-Markers (C-CB), please find here below the updated set of tables.

Please note that these tables represent information that were completed by the manufacturer. If after posting, the manufacturer notes any error, please email me ASAP, so these can be corrected. Also note that manufacturers may have submitted assays they claim to be ‘high sensitivity’ that do not meet the IFCC requirements of: a) ≤10% CV at the 99th percentile and b) ≥50% measurable concentrations ≥ LoD (Apple FS, Jaffe AS, Collinson P, Mockel M, Ordonez-Llanos J, Lindahl B, Hollander J, Plebani M, Than M, Chann MHM, on behalf of the IFCC Task Force on Clinical Applications of Cardiac Bio-Markers. IFCC educational materials on selected analytical and clinical applications of high-sensitivity cardiac troponin assays. Clin Biochem 2015: 2015;48:201-203).

As a Committee we have not altered their information.

I thank Amy Saenger PhD for her dedication to this project.

Peace

Fred Apple PhD, Chair IFCC C-CB

Click on the titles to download the documents:

Tables posted on 11 May 2022:

List of Corresponding Members, nominated by National Societies

Name

Full and Affiliate Member Societies
Caroline Le GoffRoyal Belgian Society of Laboratory Medicine (RBSLM)
Angelika Hammerer LercherSwiss Society of Clinical Chemistry (SSCC)
Galina ZemtsovskajaEstonian Society of Laboratory Medicine
Hannsjoerg BaumDeutsche Gesellschaft für Klinische Chemie und Laboratoriumsmedizin e.V. (DGKL)
Mamta KantraAssociation of Clinical Biochemists of India (ACBI)
Monica MionItalian Society of Clinical Chemistry and Clinical Molecular Biology (SIBioC)
Hiroshi YoshidaJapan Society of Clinical Chemistry (JSCC)
Dovile KarciauskaiteLithuanian Society of Laboratory Medicine
Steven MeexNederlandse Vereniging voor Klinische Chemie en Laboratoriumgeneeskunde (NVKC)
Akinosun BayoAssociation of Clinical Chemists Nigeria (ACCN)
Lakminda ThilakarathnaAssociation for Clinical Biochemistry, Sri Lanka
Aylin  Hakligor

Turkish Biochemical Society (TBS)

List of Corresponding Members, nominated by Corporate Members

NameCorporate members
Tricia RavalicoABBOTT Laboratories
Adam MossABBOTT APOC
Lindsay SunBECKMAN COULTER
Robert ZukET HEALTHCARE
Geert JannesFUJIREBIO Europe
Brian DuChateauLumiraDX
Yan LiuMINDRAY
Frank Ocklenburg     PHC Europe B.V.
Jakob EriksenRADIOMETER
Albert GesaROCHE Diagnostics
Kalen NissenSIEMENS Healthineers
HuiJun CuiSNIBE


Corporate Members Support

Corporate membersLEVEL SUPPORT
ABBOTTPLATINUM LEVEL SUPPORT
ALERECRYSTAL LEVEL SUPPORT
ET HEALTHCAREBRONZE LEVEL SUPPORT
ORTHO CLINICAL DIAGNOSTICSGOLD LEVEL SUPPORT
RADIOMETERBRONZE LEVEL SUPPORT
SIEMENS HealthineersGOLD LEVEL SUPPORT
BECKMAN COULTERSILVER LEVEL SUPPORT
ROCHESILVER LEVEL SUPPORT


List of addresses

Chair

Prof. Fred APPLE
Hennepin Healthcare / Hennepin County Medical Center
Professor, Laboratory Medicine and Pathology
University of Minnesota School of Medicine
Clinical Laboratories P4
701 Park Avenue
Minneapolis MN 55415 US
Tel.: +1  612 873 3324
email: apple004@umn.edu

Members

 

Dr Peter KAVSAK
McMaster University and Hamilton Health Sciences
Juravinski Hospital and Cancer Center
711 Concession Rd
L8V 1C3 Hamilton - CA

Prof Ola HAMMARSTEN

Professor and Senior Physician in Clinical Chemistry
Sahlgrenska Academy at the University of Gothenburg
Institute of Biochemistry, Dep.of Laboratory Medicine
Bruna stråket 16
SE-41345 Gothenburg, SE

Dr Kristin Moberg Aakre
Senior Physician, Hormone Laboratory,
Haukeland University Hospital
Associated Professor Dep.of Clinical Science,
University, Bergen, NO

Dr Amy SAENGER 
Hennepin Healthcare / Hennepin County Medical Center
Associate Professor, Laboratory Medicine and Pathology
University of Minnesota School of Medicine
Clinical Laboratories P4
701 Park Avenue
Minneapolis MN 55415 US
Tel.: +1  612 873 8709

Dr Richard BODY
Emergency Medicine Research Office,
Emergency Department,
Manchester Royal Infirmary,
Oxford Road,
Manchester,
M13 9WL, UK
Prof. Nick MILLS

Consultants

Dr. Paul O. COLLISON
Department of Chemical Pathology
2nd Floor Jenner Wing
St George's Hospital
Blackshaw Road
London SW17 0QT UK
Tel.: +44  208 725 5934

Dr. Allan JAFFE
Cardiovascular Division, Gonda 5
Mayo Clinic
200 First Street SW
Rochester - MN 55905
USA 
Tel.: +1 507 284 1648

Dr. Jordi ORDÓÑEZ-LLANOS
Senior Consultant, Biochemistry Dept.
Hospital de Sant Pau
Professor of Clinical Biochemistry
Universitat Autònoma
Barcelona - Spain
Tel.: +34 935537359

Dr Torbjørn OMLAND
Akershus Universitetssykehus
1478 Lørenskog - NO
 
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