Advancing excellence in laboratory medicine for better healthcare worldwide

Committee on Clinical Applications of Cardiac Bio-Markers (C-CB)

Membership

NamePositionCountryTermTime in Office
F. AppleChairUS2nd2020 01 - 2022 12
P. KavsakMemberCA2nd2020 01 - 2022 12
O. HammarstenMemberSE1st2020 01 -2022 12
A. SaengerMemberUS2nd2020 01 - 2022 12
R. BodyMemberUK2nd2020 01 - 2022 12
SPC LamMemberSG2nd2020 01 - 2022 12
K. Moberg AakreMemberNO1st2021 01 - 2023 12
P. CollinsonConsultantUK
A. JaffeConsultantUS
J. Ordoñez-LlanosConsultantES
T. OmlandConsultantNO

Terms of Reference

  • Education; Established and novel cardiac biomarkers
  • Biochemistry of cardiac biomarkers
  • Clinical use of cardiac biomarkers: risk stratification, diagnostics, therapy
  • Laboratory issues on cardiac biomarkers: 99th percentiles, delta values, biological variation, quality specifications of assays

C-CB Published Manuscripts:

2021

Getting Cardiac Troponin Right: Appraisal of the 2020 European Society of Cardiology Guidelines for the
Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation by
the International Federation of Clinical Chemistry and Laboratory Medicine Committee on Clinical Applications of Cardiac Bio-Markers.

Fred S. Apple*, Paul O. Collinson, Peter A. Kavsak, Richard Body, Jordi Ordonez-Llanos, Amy K. Saenger, Torbjorn Omland, Ola Hammarsten,Allan S. Jaffe; on behalf of the IFCC Committee on Clinical Applications of Cardiac Bio-Markers . Clinical Chemistry 1-6 (2021).

2020

Implementation of High-Sensitivity and Point-of-Care Cardiac Troponin Assays into Practice: Some Different Thoughts.

Fred S. Apple*, Corinne R. Fantz and Paul O. Collinsonc, on behalf of the IFCC Committee on Clinical
Application of Cardiac Bio-Markers. Clinical Chemistry 1-9 (2020)

2019

High sensitivity, contemporary and point-of-care cardiac troponin assays: educational aids developed by the IFCC Committee on Clinical Application of Cardiac Bio-Markers.

Paul O. Collinson, Amy K. Saenger and Fred S. Apple*, on behalf of the IFCC C-CB. Clin Chem Lab Med 2019; 57(5): 623–632

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Cardiac troponin and natriuretic peptide analytical interferences from hemolysis and biotin: educational aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB).

Amy K. Saenger, Allan S. Jaffe, Richard Body, Paul O. Collinson, Peter A. Kavsak, Carolyn S.P. Lam, Guillaume Lefèvre, Tobjørn Omland, Jordi Ordóñez-Llanos, Kari Pulkki and Fred S. Apple*. Clin Chem Lab Med 2019; 57(5): 633–640.

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Educational Recommendations on Selected Analytical and Clinical Aspects of Natriuretic Peptides with a Focus on Heart Failure: A Report from the IFCC C-CB.

Peter A. Kavsak, Carolyn S.P. Lam, Amy K. Saenger, Allan S. Jaffe, Paul Collinson, Kari Pulkki,Tobjørn Omland, Guillaume Lefevre, Richard Body, Jordi Ordonez-Llanos and Fred S. Apple*.  Clinical Chemistry 65:10 1221–1227 (2019).

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Use of troponins in clinical practice: Evidence in favour of use of troponins in clinical practice.
Evidence in favour of use of troponins in clinical practice

Paul O Collinson , Fred Apple*, Allan S Jaffe. Collinson PO, et al. Heart 2019;0:1–3. doi:10.1136/heartjnl-2019-315622

2018

Clinical Laboratory Practice Recommendations for the Use of Cardiac Troponin in Acute Coronary Syndrome: Expert Opinion from the Academy of the American Association for Clinical Chemistry and the Task Force on Clinical Applications of Cardiac Bio-Markers of the
International Federation of Clinical Chemistry and Laboratory Medicine.

Alan H.B. Wu*, Robert H. Christenson, Dina N. Greene, Allan S. Jaffe, Peter A. Kavsak,
Jordi Ordonez-Llanos,and Fred S. Apple. Clinical Chemistry 64:4 645–655 (2018). 

2017

Cardiac Troponin Assays: Guide to Understanding Analytical Characteristics and Their Impact on Clinical Care.

Fred S. Apple,* Yader Sandoval, Allan S. Jaffe, and Jordi Ordonez-Llanos, for the IFCC Task Force on Clinical Applications of Cardiac Bio-Markers. Clinical Chemistry 63:1
73–81 (2017).

2015

IFCC educational materials on selected analytical and clinical applications of high sensitivity cardiac troponin assays.

Fred S. Apple, Allan S. Jaffe, Paul Collinson, Martin Mockel, Jordi Ordonez-Llanos, Bertil Lindahl, Judd Hollander, Mario Plebani, Martin Than, M.H.M. Chan on behalf of the International Federation of Clinical Chemistry (IFCC) Task Force on Clinical Applications of
Cardiac Bio-Markers. Vlinical Biochemistry (48) 2015 201-203.

2012

Analytical Characteristics of High-Sensitivity Cardiac Troponin Assays.

Fred S. Apple and Paul O. Collinson, for the IFCC Task Force on Clinical Applications of Cardiac Biomarkers. Clinical Chemistry 58:1 54–61 (2012)

Current Projects

  • Development of educational materials about high-sensitivity, contemporary and point of care cardiac troponin assay use in clinical practice.
  • Development of educational materials about natriuretic peptide assay use in clinical practice
  • Development of educational expert opinion materials in collaboration with The Academy of the AACC on the use of cardiac troponin in coronary disease
  • Updating cardiac troponin and natriuretic peptide assay tables by both manufacturer claims and from peer-reviewed literature
  • Distribution of educational posters and mouse-pads addressing high sensitivity cardiac troponin assays at IFCC meetings in 2017 and in 2018.
  • Distribution of flash keys at AACC 2019.

05 December, 2019

On behalf of the members of the IFCC Committee on Clinical Applications of Cardiac Bio-Markers (C-CB), we post our fourth 2019 set of tables, updating the analytical characteristics of contemporary, point of care (POC) and high sensitivity (hs) cardiac troponin I and T assays; as provided by the manufacturer to the C-CB.

Please note that these tables represent information that were completed by the manufacturer. If after posting, the manufacturer notes any error, please email me ASAP, so these can be corrected. Also note that manufacturers may have submitted assays they claim to be ‘high sensitivity’ that do not meet the IFCC requirements of: a) ≤10% CV at the 99th percentile and b) ≥50% measurable concentrations ≥ LoD (Apple FS, Jaffe AS, Collinson P, Mockel M, Ordonez-Llanos J, Lindahl B, Hollander J, Plebani M, Than M, Chann MHM, on behalf of the IFCC Task Force on Clinical Applications of Cardiac Bio-Markers. IFCC educational materials on selected analytical and clinical applications of high-sensitivity cardiac troponin assays. Clin Biochem 2015: 2015;48:201-203).

As a Committee we have not altered their information.

It is the plan of the IFCC C-CB to update these tables every 6 months. Therefore, we encourage both industry and investigators to email me any new or updated assay information based on research publications or regulatory approval package inserts, to assist in our table updates.

Peace

Fred Apple PhD, Chair IFCC C-CB

apple004@umn.edu

28 August 2020

We post our first table updates for the 21st century. We apologize for the delay since last updated, as the COVID-19 global pandemic has affected all our lives in so many ways. We hope all are well and safe and these updates continue to assist your practices. I thank Amy Saenger PhD for her dedication to this project.

Peace

Fred Apple PhD, Chair IFCC C-CB

19 April 2021

On behalf of the members of the IFCC Committee on Clinical Applications of Cardiac Bio-Markers (C-CB), please find here below the updated set of tables.

Click on the titles to download the documents:

Tables posted 19 April 2021:

List of Corresponding Members, nominated by National Societies

Name

Full and Affiliate Member Societies
Caroline Le GoffRoyal Belgian Society of Laboratory Medicine (RBSLM)
Galina ZemtsovskajaEstonian Society of Laboratory Medicine
Hannsjoerg BaumDeutsche Gesellschaft für Klinische Chemie und Laboratoriumsmedizin e.V. (DGKL)
Monica MionItalian Society of Clinical Chemistry and Clinical Molecular Biology (SIBioC)
Hiroshi YoshidaJapan Society of Clinical Chemistry (JSCC)
Dovile KarciauskaiteLithuanian Society of Laboratory Medicine
Steven MeexNederlandse Vereniging voor Klinische Chemie en Laboratoriumgeneeskunde (NVKC)
Akinosun BayoAssociation of Clinical Chemists Nigeria (ACCN)
Lakminda ThilakarathnaAssociation for Clinical Biochemistry, Sri Lanka
Aylin  Hakligor

Turkish Biochemical Society (TBS)

List of Corresponding Members, nominated by Corporate Members

NameCorporate members
Tricia RavalicoABBOTT Laboratories
Adam MossABBOTT APOC
Lindsay SunBECKMAN COULTER
Robert ZukET HEALTHCARE
Geert JannesFUJIREBIO Europe
Frank Ocklenburg     PHC Europe B.V.
Jakob EriksenRADIOMETER
Gesa Ines AlbertROCHE Diagnostics
Kalen OlsonSIEMENS Healthineers


Corporate Members Support

Corporate membersLEVEL SUPPORT
ABBOTTPLATINUM LEVEL SUPPORT
ALERECRYSTAL LEVEL SUPPORT
ET HEALTHCAREBRONZE LEVEL SUPPORT
ORTHO CLINICAL DIAGNOSTICSGOLD LEVEL SUPPORT
RADIOMETERBRONZE LEVEL SUPPORT
SIEMENS HealthineersGOLD LEVEL SUPPORT
BECKMAN COULTERSILVER LEVEL SUPPORT
ROCHESILVER LEVEL SUPPORT


List of addresses

Chair

Dr Fred APPLE
Hennepin Healthcare / Hennepin County Medical Center
Professor, Laboratory Medicine and Pathology
University of Minnesota School of Medicine
Clinical Laboratories P4
701 Park Avenue
Minneapolis MN 55415 US
Tel.: +1  612 873 3324
email: apple004@umn.edu

Members

 

Dr Peter KAVSAK
McMaster University and Hamilton Health Sciences
Juravinski Hospital and Cancer Center
711 Concession Rd
L8V 1C3 Hamilton - CA

Prof Ola HAMMARSTEN

Professor and Senior Physician in Clinical Chemistry
Sahlgrenska Academy at the University of Gothenburg
Institute of Biochemistry, Dep.of Laboratory Medicine
Bruna stråket 16
SE-41345 Gothenburg, SE

Dr Kristin Moberg Aakre
Senior Physician, Hormone Laboratory,
Haukeland University Hospital
Associated Professor Dep.of Clinical Science,
University, Bergen, NO

Dr Amy SAENGER 
Hennepin Healthcare / Hennepin County Medical Center
Associate Professor, Laboratory Medicine and Pathology
University of Minnesota School of Medicine
Clinical Laboratories P4
701 Park Avenue
Minneapolis MN 55415 US
Tel.: +1  612 873 8709

Dr Richard BODY
Emergency Medicine Research Office,
Emergency Department,
Manchester Royal Infirmary,
Oxford Road,
Manchester,
M13 9WL, UK
Dr Su Ping Carolyn LAM
National Heart Centre Singapore
SingHealth Duke-NUS Cardiovascular Academic Clinical Programme
and Department of Cardiology
5 Hospital Drive
Singapore 169609 - SG

Consultants

Dr. Paul O. COLLISON
Department of Chemical Pathology
2nd Floor Jenner Wing
St George's Hospital
Blackshaw Road
London SW17 0QT UK
Tel.: +44  208 725 5934

Dr. Allan JAFFE
Cardiovascular Division, Gonda 5
Mayo Clinic
200 First Street SW
Rochester - MN 55905
USA 
Tel.: +1 507 284 1648

Dr. Jordi ORDÓÑEZ-LLANOS
Senior Consultant, Biochemistry Dept.
Hospital de Sant Pau
Professor of Clinical Biochemistry
Universitat Autònoma
Barcelona - Spain
Tel.: +34 935537359

Dr Torbjørn OMLAND
Akershus Universitetssykehus
1478 Lørenskog - NO
 
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