Advancing excellence in laboratory medicine for better healthcare worldwide

Molecular Diagnostic Network Laboratories

Click here to download the MDC Document: Process for review of applications and selection of Molecular Diagnostic Centers

Click here to download the " Molecular Diagnostics Centers Network APPLICATION FORM" and the " Molecular Diagnostics Expert APPLICATION FORM"

About the Molecular Diagnostic Centres (MDC) Project of IFCC C-MD

Each MDC which is formed will represent an interface between the IFCC C-MD and clinical laboratories performing molecular diagnostic tests. The MDC concept was formulated to promote formation of an international network of molecular diagnostic laboratories and to encourage close collaboration within this network. This approach supports the IFCC-CMD's broader initiatives for excellence and international collaborations in molecular diagnostics.

Terms of reference of the MDCs

  • To provide a point of contact to Molecular Diagnostic Laboratories in the analysis and/or interpretation of complex analytical/clinical scenarios.
  • To participate in international studies involving the evaluation of new methodological approaches.


MDC fields of application and joining a MDC Expert Laboratory

Individuals and organizations can apply to join an MDC network by completion of an application form. There are two levels of participation, including participation as an IFCC MDC Network Member or as an IFCC MDC Expert Laboratory.

IFCC MDC Expert Laboratories will be engaged at a higher level and act as a point of reference within a special area of interest within the IFCC MDC Network. Progress reports on the activities of Expert Laboratories are submitted to the C-MD for review. Further details are available on the application form.

Examples of fields of application

  • cystic fibrosis,
  • haemochromatosis
  • dyslipidaemias Fragile X
  • pharmacogenetics

Examples of molecular oncology fields of application

  • breast cancer
  • melanoma
  • gene amplification circulating tumour cells
  • laser microdissection
  • acquired rearrangements

CANADA

Dr. Lianna Kyriakopoulou 
Hospital for Sick Children
Department of Paediatric Laboratory Medicine
Division of Genome Diagnostics
555 University Avenue
Toronto,  Ontario
M5G 1X8
E-mail: Lianna.kyriakopoulou@sickkids.ca

MDC Network Area of Interest

 

Examples

Specific Area

Single-Gene Disorders

Hemochromatosis, Fragile X, Cystic Fibrosis, Factor V Leiden

CF, FRX Beckwith-Wiedeman, Angelman, achndroplasia, 22q11.2 deletion, DMD, dopamine beta-hydroxylase, cherubism, CHARGE, Caffey, BOR syndrome, BMT, X-chromosome inactivation, thanatophoric dysplasia, Trismus-pseudocamptomegaly, SMA, SMB, Simpson Golabi, SBDS, Russel Silver, retinoblastoma, Prader Willi, DFN3/4,Li-Fraumeni, Hunter, Noonan, Neurofibromatosis, HLH MAS, arrhythmic right venricular cardiomyopathy, connective tissue, craniosynostosis, congenital muscular dystrophies, complement based renal disease, NCL, mitochondrial hearing loss, hereditary spastic paraplegia, hereditary hemorrhagic telangiectasia, USHER, Stickler, hereditary hearing loss (9 genes), non-syndromic hearing loss, focal segmental glomerulosclerosis 

Multi-Gene Disorders

Dyslipidaemias

OncologySolid Organ: Breast, colon, lungs, therapeutic response, prognostic testing
Hematological: Bcr-Abl quantitative PCR, B and T cell clonality
Circulating Tumor Cells, Circulating cell free DNA
PharmacogeneticsPharmacogenetics
Inherited Errors of metabolismglycogen storage disease, phenylketonuria, porphyria,  Lesch-Nyhan syndromeHunter, Fabry, Gaucher, CLN, mitochondrial,hearing loss, (WES) exome sequencing
Infectious DiseasesSexually transmitted diseases, Respiratory diseases, Meningitis/Encephalitis, Hepatitis, Gastrointestinal diseases, Tropical diseases, Pediatric diseases, Drug resistance genes
Circulating cell free DNACirculating cell free DNA, Massively parallel sequencing data analysis for cell free DNA, Noninvasive prenatal testing
Bioinformatics and Laboratory information systemsMassively parallel sequencing data analysis, patient management algorithms, instrument interface
External Quality AssessmentProficiency testing, alternate assessment (specimen exchange)
Reference MaterialsCalibrators, Certified reference materials, Low level materials
EducationUser education i.e. website, health care provider (example, nurse and doctor education), Laboratory and workflow design

FRANCE

Dr. Emmanuelle DeRaucourt
APHP, HUPNVS, Beaujon
Hématologie Biologique
100, bd du Général Leclerc
92118 Clichy Cédex
France
E-mail: emmanuelle.de-raucourt@aphp.fr


Co-Applicants:
Dr. Katell Peoc’h
E-mail: katell.peoch@aphp.fr
Dr. Larbi Boudaoud
E-mail: larbi.boudaoud@aphp.fr
Dr. Catherine Trichet
E-mail: Catherine.trichet@aphp.fr

MDC Network Area of Interest

 

Examples

Specific Area

Single-Gene Disorders

Hemochromatosis, Fragile X, Cystic Fibrosis, Factor V Leide

Hemostasis disorders

Multi-Gene Disorders

Dyslipidaemias

Oncology

Solid Organ: Breast, colon, lungs, therapeutic response, prognostic testing

Hematological: Bcr-Abl quantitative PCR, B and T cell clonalityJak2 mutations
Circulating Tumor Cells, Circulating cell free DNA
PharmacogeneticsCYP2D6, TPMT
Inherited Errors of metabolismglycogen storage disease, phenylketonuria, porphyria,  Lesch-Nyhan syndrome
Infectious DiseasesSexually transmitted diseases, Respiratory diseases, Meningitis/Encephalitis, Hepatitis, Gastrointestinal diseases, Tropical diseases, Pediatric diseases, Drug resistance genes
Circulating cell free DNACirculating cell free DNA, Massively parallel sequencing data analysis for cell free DNA, Noninvasive prenatal testing
Bioinformatics and Laboratory information systemsMassively parallel sequencing data analysis, patient management algorithms, instrument interface
External Quality AssessmentProficiency testing, alternate assessment (specimen exchange)
Reference MaterialsCalibrators, Certified reference materials, Low level materials
EducationUser education i.e. website, health care provider (example, nurse and doctor education), Laboratory and workflow designX (Anticoagulants clinic)

HONG KONG

Dr. Chan, On Kei Angel

Division of Clinical Biochemistry 
Department of Pathology & Clinical Biochemistry 
LG1, Block K 
Queen Mary Hospital 
102 Pokfulam Road
Hong Kong
E-mail: cok436@ha.org.hk


Co-Applicant: Dr. Chung Him See
E-mail:  sch121@ha.org.hk

MDC Network Area of Interest

 

Examples

Specific Area

Single-Gene Disorders

Hemochromatosis, Fragile X, Cystic Fibrosis, Factor V Leiden

Neurological disorders, congenital myopathies, mitochondrial diseases, inherited endocrinolopathies, disorders of sex development

Multi-Gene Disorders

Dyslipidaemias

 

Oncology

Solid Organ: Breast, colon, lungs, therapeutic response, prognostic testing

Hematological: Bcr-Abl quantitative PCR, B and T cell clonality

Circulating Tumor Cells, Circulating cell free DNA
PharmacogeneticsCYP2D6, TPMT
Inherited Errors of metabolismglycogen storage disease, phenylketonuria, porphyria,  Lesch-Nyhan syndromeCongenital adrenal hyperplasia, steroid metabolic diseases, amino acid disorders, organic acid disorders
Infectious DiseasesSexually transmitted diseases, Respiratory diseases, Meningitis/Encephalitis, Hepatitis, Gastrointestinal diseases, Tropical diseases, Pediatric diseases, Drug resistance genes
Circulating cell free DNACirculating cell free DNA, Massively parallel sequencing data analysis for cell free DNA, Noninvasive prenatal testing
Bioinformatics and Laboratory information systemsMassively parallel sequencing data analysis, patient management algorithms, instrument interface

PARAGUAY

Dr. Russomando Graciela
Head of Department
Molecular Biology and Biotechnology Department
Instituto de Investigaciones en Ciencias de la Salud
Universidad Nacional de Asuncion, Campus Universitario
Dr Cecilio Baez c/ Dr Gaspar Villamayor
San Lorenzo, Po Box 2160
Paraguay
E-mail:  grusso@rieder.net.py

MDC Network Area of Interest

 

Examples

Specific Area

Single-Gene Disorders

Hemochromatosis, Fragile X, Cystic Fibrosis, Factor V Leiden

Multi-Gene Disorders

Dyslipidaemias

Oncology

Solid Organ: Breast, colon, lungs, therapeutic response, prognostic testing

Breast, colon, lungs, therapeutic response, prognostic testing

Hematological: Bcr-Abl quantitative PCR, B and T cell clonality

Circulating Tumor Cells, Circulating cell free DNA

Circulating Tumor Cells, Circulating cell free DNA
Pharmacogenetics

CYP2D6, TPMT

Inherited Errors of metabolism

glycogen storage disease, phenylketonuria, porphyria,  Lesch-Nyhan syndrome

Infectious Diseases

Sexually transmitted diseases, Respiratory diseases, Meningitis/Encephalitis, Hepatitis, Gastrointestinal diseases, Tropical diseases, Pediatric diseases, Drug resistance genes

Children and adults health. , Respiratory diseases, Meningitis/Encephalitis, Gastrointestinal diseases, Tropical diseases, Drug resistance genes
Circulating cell free DNA

Circulating cell free DNA, Massively parallel sequencing data analysis for cell free DNA, Noninvasive prenatal testing

Bioinformatics and Laboratory information systems

Massively parallel sequencing data analysis, patient management algorithms, instrument interface

External Quality Assessment

Proficiency testing, alternate assessment (specimen exchange)

Reference Materials

Calibrators, Certified reference materials, Low level materials

Education

User education i.e. website, health care provider (example, nurse and doctor education), Laboratory and workflow design

Laboratory and workflow design

TURKEY

Dr. Guzel Mine
Biruni Genetic Diseases Diagnostic Center 
Gursel Mahallesi Kagithane Caddesi No:14/1
Kagithane / Istanbul / Turkey
email mguzel@biruni.com.tr


Co-Applicant: 
Akcay Tan, Remin
E-mail: rakcaytan@biruni.com.tr

MDC Network Area of Interest

 

Examples

Specific Area

Single-Gene Disorders

Hemochromatosis, Fragile X, Cystic Fibrosis, Factor V Leiden

Oncology

Solid Organ: Breast, colon, lungs, therapeutic response, prognostic testing

Hematological: Bcr-Abl quantitative PCR, B and T cell clonality

Pharmacogenetics

CYP2D6, TPMT

Infectious Diseases

Sexually transmitted diseases, Respiratory diseases, Meningitis/Encephalitis, Hepatitis, Gastrointestinal diseases, Tropical diseases, Pediatric diseases, Drug resistance genes

Circulating cell free DNA

Circulating cell free DNA, Massively parallel sequencing data analysis for cell free DNA, Noninvasive prenatal testing

 
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