Advancing excellence in laboratory medicine for better healthcare worldwide

Reference Intervals and Decision Limits (C-RIDL)


NamePositionCountryTermTime in Office
T. StreichertChairDE1st2022 01 - 2024 12
N. BrouwerMemberNL1st2022 04 - 2024 12
Y. KatariaMemberUS1st2020 03 - 2022 12
K. Rodríguez-CapoteMemberCA1st2022 04 - 2024 12
K. SikarisMemberAU2nd2020 01 - 2022 12
Y. OzardaConsultant

Terms of Reference

  • To review current concepts of establishing reference intervals and decision limits and to prepare state-of-the-art position statements regarding new avenues
  • To make available reference intervals and decision limits that respect the requirements of international directives such as the European IVD Directive 98/79, and relevant ISO standards
  • To determine priority list of measurands (analytes) for which reference intervals and/or decision limits have to be developed, considering various factors, such as age, gender, ethnicity, and for which the greatest improvements in medical decision making are anticipated
  • To monitor and evaluate currently proposed reference intervals for selected measurands (analytes) in the light of the concept of traceability and of the identification of the uncertainty
  • To establish transferabilty protocols of reference intervals and decision limits, which take into consideration inter-routine laboratory method variations and achieve better applicability in clinical practice
  • To collaborate with other organizations and/or to undertake establishment of reference intervals or decision limits for measurands (analytes) identified as a priority
  • To work in close collaboration with other Cs and WGs of SD and other IFCC Divisions for the development and appropriate clinical utilization of reference intervals and decision limits

Current Projects

  • Conduction of a new study to compare alternative approaches (conventional and big data) for the determination of reference intervals
  • Creating a website to provide the reference intervals obtained from the global study for practice of Evidence Based Laboratory Medicine
  • Preparation of a publication on comparison direct and indirect approaches for the determination of reference intervals.

The published 2 papers on Clinica Chimica Acta (CCA) about the results of Global Reference Intervals Study performed by C-RIDL are downloadable at following links:

"A global multicenter study on reference values"
Part 1: Assessment of methods for derivation and comparison of reference intervals
Part 2: Exploration of sources of variation across the countries

List of Corresponding Members, nominated by National Societies

NameFull and Affiliate Member Societies
Matias Gastón DombaldConfederación Unificada Bioquímica de la Republica Argentina (CUBRA)
Graham JonesAustralasian Association for Clinical Biochemistry and Laboratory Medicine (AACB)
Natasha SlhessarenkoSociedade Brasileira de Patologia Clínica/Medicina Laboratorial (SBPC/ML)
Jasna Leniček KrležaCroatian Society of Medical Biochemistry and Laboratory Medicine (CSMBLM)
Samuel Kinde BirruEthiopian Medical Laboratory Association (EMLA)
Georg HoffmannDeutsche Gesellschaft für Klinische Chemie und Laboratoriumsmedizin e.V. (DGKL)
Julia TrifonidiGreek Society of Clinical Chemistry - Clinical Biochemistry (GSCC-CB)
Barnali DasAssociation of Clinical Biochemists of India (ACBI)
Amita YadavAssociation of Medical Biochemists of India (AMBI)
Anak Agung WiradewiIndonesian Association for Clinical Chemistry (HKKI)
Romolo DorizziItalian Society of Clinical Chemistry and Clinical Molecular Biology (SIBioC)
Kiyohide IshikuraJapan Society of Clinical Chemistry (JSCC)
Valdas BanysLithuanian Society of Laboratory Medicine
Raja Elina Raja AziddinMalaysian Association of Clinical Biochemists (MACB)
Danica PopovićMontenegrian Association of Clinical Chemistry and Laboratory Medicine
Layachi ChabraouiSociété Marocaine de Chimie Clinique (SMCC)
Ram Vinod MahatoNepalese Association for Clinical Chemistry (NACC)
Maria EbesununAssociation of Clinical Chemists Nigeria (ACCN)
Joakim EikelandNorwegian Society of Medical Biochemistry (NSMB)
Salma HaqPakistan Society of Chemical Pathologists
Anacleta P. ValdezPhilippine Council for Quality Assurance in Clinical Laboratories (PCQACL)
Gernand WojciechPolish Society for Laboratory Diagnostics (PTDL)
Svetlana EvginaAssociation of Lab Specialists and Org «Federation of Laboratory Medicine» (FLM)
Rajiv ErasmusSouth African Association of Clinical Biochemistry
Bolonghoge DayanathAssociation for Clinical Biochemistry, Sri Lanka
Olivier Boulat
Swiss Society of Clinical Chemistry (SSCC)
Carlos LacavaAsociación Bioquímica Uruguaya (ABU)
Hoang Thu HaVietnamese Association of Clinical Biochemists (VACB)

List of Corresponding Members, nominated by Corporate Members

NameCorporate Memeber
Christian FischerABBOTT Diagnostics
Frank OcklenburgP.H.C. Europe
Horst KlimaROCHE Diagnostics
Jeanne Rhea-McManusSIEMENS

Committee Chair's contact

Dr. Thomas Streichert
Director Central Laboratory
Institute of Clinical Chemistry of the University of Cologne

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