Advancing excellence in laboratory medicine for better healthcare worldwide

Molecular Diagnostic Centres Expert Laboratory

 

Click here to download the MDC Document: Process for review of applications and selection of Molecular Diagnostic Centers  

Click here to download the " Molecular Diagnostics Centers Network APPLICATION FORM" and the " Molecular Diagnostics Expert APPLICATION FORM"

 

About the Molecular Diagnostic Centres (MDC) Project of IFCC C-MD

Each MDC which is formed will represent an interface between the IFCC C-MD and clinical laboratories performing molecular diagnostic tests. The MDC concept was formulated to promote formation of an international network of molecular diagnostic laboratories and to encourage close collaboration within this network. This approach supports the IFCC-CMD's broader initiatives for excellence and international collaborations in molecular diagnostics.

 

Terms of reference of the MDCs

  • To provide a point of contact to Molecular Diagnostic Laboratories in the analysis and/or interpretation of complex analytical/clinical scenarios.
  • To participate in international studies involving the evaluation of new methodological approaches. 


MDC fields of application and joining a MDC Expert Laboratory

Individuals and organizations can apply to join an MDC network by completion of an application form. There are two levels of participation, including participation as an IFCC MDC Network Member or as an IFCC MDC Expert Laboratory.

IFCC MDC Expert Laboratories will be engaged at a higher level and act as a point of reference within a special area of interest within the IFCC MDC Network. Progress reports on the activities of Expert Laboratories are submitted to the C-MD for review. Further details are available on the application form.

Examples of fields of application

  • cystic fibrosis,
  • haemochromatosis
  • dyslipidaemias Fragile X
  • pharmacogenetics

Examples of molecular oncology fields of application

  • breast cancer
  • melanoma
  • gene amplification circulating tumour cells
  • laser microdissection
  • acquired rearrangements 

 

AUSTRIA 

Assoc. Prof., Dr. phil. Robert Zeillinger
Assoc. Prof. of Tumor biology
Molecular Oncology Group
Department of Obstetrics and Gynecology
Medical University of Vienna
Waehringer Guertel 18-20, 5Q
A-1090 Vienna
Austria
E-mail: robert.zeillinger@meduniwien.ac.at

Co-Applicant: Dr. Obermayr Eva
email: Eva.obermayr@meduniwien.ac.at

 

   

MDC Network Area of Interest

 

Examples

Specific Area

Single-Gene Disorders

Hemochromatosis, Fragile X, Cystic Fibrosis, Factor V Leiden

 

Multi-Gene Disorders

Dyslipidaemias

 

Oncology 

Solid Organ: Breast, colon, lungs, therapeutic response, prognostic testing

Breast, lung, ovarian, prognostic & predictive testing; early detection

 

Hematological: Bcr-Abl quantitative PCR, B and T cell clonality

 
Pharmacogenetics CYP2D6, TPMT  
Inherited Errors of metabolism glycogen storage disease, phenylketonuria, porphyria,  Lesch-Nyhan syndrome  
Infectious Diseases Sexually transmitted diseases, Respiratory diseases, Meningitis/Encephalitis, Hepatitis, Gastrointestinal diseases, Tropical diseases, Drug resistance, Pediatric diseases  
Circulating cell free DNA, Circulating Tumor Cells Noninvasive prenatal testing, prognosis testing, therapeutic response CTC detection and molecular analysis
Bioinformatics and Laboratory information systems Massively parallel sequencing data analysis, patient management algorithms, instrument interface  
Education User education i.e. website, health care provider (example, nurse and doctor education), Laboratory and workflow design  

 

CANADA 

Dr. Yves Giguère, MD, PhD, FRCPC
Laboratory Director, Molecular Diagnostics, Biochemistry
CHU de Québec
Université Laval
Service de biochimie médicale
Hôpital St-François d’Assise
local A2-402
10, rue de l’Espinay
Québec, QC, Canada G1L 3L5
E-mail: Yves.Giguere@crchudequebec.ulaval.ca

Co-Applicant: Dr. François Rousseau
E-mail: Francois.rousseau@fmed.ulaval.ca

 

MDC Network Area of Interest

 

Examples

Specific Area

Single-Gene Disorders

Hemochromatosis, Fragile X, Cystic Fibrosis, Factor V Leiden

Fragile X, Fragile E, Hemochromatosis, Cystic fibrosis, Tyrosinemia, ACCPN

Multi-Gene Disorders

Dyslipidaemias

 
Oncology Solid Organ: Breast, colon, lungs, therapeutic response, prognostic testing  
  Hematological: Bcr-Abl quantitative PCR, B and T cell clonality  
Pharmacogenetics CYP2D6, TPMT  
Inherited Errors of metabolism glycogen storage disease, phenylketonuria, porphyria,  Lesch-Nyhan syndrome  
Infectious Diseases Sexually transmitted diseases, Respiratory diseases, Meningitis/Encephalitis, Hepatitis, Gastrointestinal diseases, Tropical diseases, Pediatric diseases, Drug resistance genes  
Circulating cell free DNA Noninvasive prenatal testing, prognostic testing, therapeutic response  NIPT
Bioinformatics and Laboratory information systems Massively parallel sequencing data analysis, patient management algorithms, instrument interface  NGS data analysis
Education User education i.e. website, health care provider (example, nurse and doctor education), Laboratory and workflow design  
Other NGS applied to newborn screening  

 

GERMANY 

Dr. Beniamin Ghebremedhin
HELIOS Klinikum Wuppertal
Witten Herdecke University
Institute for Med. Laboratory Diagnostics
Heusnerstr. 40
42283 Wuppertal
Germany
E-mail: beniam.ghebremedhin@helios-kliniken.de

Co-Applicant:  Prof. Dr. med. Parviz Ahmad-Nejad
E-mail: parviz.ahmad-nejad@helios-kliniken.de

 

MDC Network Area of Interest

 

Examples

Specific Area

Single-Gene Disorders

Hemochromatosis, Fragile X, Cystic Fibrosis, Factor V Leiden

Fragile X, Fragile E, Hemochromatosis, Cystic fibrosis, Tyrosinemia, ACCPN

Multi-Gene Disorders

Dyslipidaemias

 Dyslipidemias

Oncology

Solid Organ: Breast, colon, lungs, prognostic testing, therapeutic response

 

  Hematological: Bcr-Abl quantitative PCR, B and T cell clonality, etc...  
Pharmacogenetics CYP2D6, TPMT  
Inherited Errors of metabolism glycogen storage disease, phenylketonuria, porphyria,  Lesch-Nyhan syndrome   
Infectious Diseases Sexually transmitted diseases, Respiratory diseases, Meningitis/Encephalitis, Hepatitis, Gastrointestinal diseases, Tropical diseases, Pediatric diseases, Drug resistance  
Circulating cell free DNA, Circulating Tumor Cells Noninvasive prenatal testing, prognostic testing, therapeutic response  NIPT
Bioinformatics and Laboratory information systems Massively parallel sequencing data analysis, patient management algorithms, instrument interface  NGS data analysis
Education User education i.e. website, health care provider (example, nurse and doctor education), Laboratory and workflow design  
Other NGS applied to newborn screening  

 

GERMANY 

Prof. Dr. med. Michael Neumaier

Institute for Clinical Chemistry
Medical Faculty Mannheim of the University of Heidelberg
University Hospital Mannheim
Theodor-Kutzer-Ufer 1-3
68167 Mannheim
Germany
E-mail: michael.neumaier@medma.uni-heidelberg.de

 

MDC Network Area of Interest

 

Examples

Specific Area

Single-Gene Disorders

Hemochromatosis, Fragile X, Cystic Fibrosis, Factor V Leiden

Hemocromatosis, Thrombophilia

Oncology

Solid Organ: Breast, colon, lungs, therapeutic response, prognostic testing

Molecular Oncology
Pharmacogenetics

CYP2D6, TPMT

 

   

INDIA 

Dr. Tester F. Ashavaid
Consultant Biochemist
Head – Laboratory Medicine, Director
Lab Research
Department of Laboratory Medicine (Biochemistry Section)
D. Hinduja Hospital & Medical Research Centre
Lalita Girdhar Building
Veer Savarkar Marg, Mahim
Mumbai, 400016
India
E-mail: dr_tashavaid@hindujahospital.com

Co-Applicant: Dr. Camilla Rodrigues
Consultant Microbiologist
Department of Laboratory Medicine (Microbiology Section)
E-mail: dr_crodrigues@hindujahospital.com

 

MDC Network Area of Interest

 

Examples

Specific Area

Single-Gene Disorders

Hemochromatosis, Fragile X, Cystic Fibrosis, Factor V Leiden

 Cystic Fibrosis, Spinal muscolar atrophy

Multi-Gene Disorders

Dyslipidaemias

 

Oncology 

Solid Organ: Breast, colon, lungs, therapeutic response, prognostic testing

EGFR, KRAS, MGMT testing

 

Hematological: Bcr-Abl quantitative PCR, B and T cell clonality

 
Pharmacogenetics CYP2D6, TPMT NUDT15, TPMT, CYP2C19, CYP2C9, VKROC1, CYP4F2, CYP2D6, CYP3A5, CYP2B6
Inherited Errors of metabolism glycogen storage disease, phenylketonuria, porphyria,  Lesch-Nyhan syndrome  
Infectious Diseases Sexually transmitted diseases, Respiratory diseases, Meningitis/Encephalitis, Hepatitis, Gastrointestinal diseases, Tropical diseases, Drug resistance, Pediatric diseases Respiratory, Gastrointestinal diseases, Meningitis/Encephalitis, Hepatitis (HBV,HCV), Sexually transmitted diseases (Dengue, Chikungunya), Drug resistance - Tubercolosis, Gram Negative bacteria
Circulating cell free DNA, Circulating Tumor Cells Noninvasive prenatal testing, prognosis testing, therapeutic response CTC detection and molecular analysis
Bioinformatics and Laboratory information systems Massively parallel sequencing data analysis, patient management algorithms, instrument interface  
Education User education i.e. website, health care provider (example, nurse and doctor education), Laboratory and workflow design  

   

IRAN 

Dr. Poopak, Behzad
Lab Director
Payvand Clinical and Specialty Laboratory
Molecular Section
Unit 4, No 174
Zafar St., Shariati Ave.
Tehran
Iran
E-mail: bpoopak@gmail.com; info@payvandlab.com.com

Co-applicant: Dr. Masoumeh Rajabi Bazel
E-mail: rajabibazl_m@yahoo.com 

  

MDC Network Area of Interest

 

Examples

Specific Area

Single-Gene Disorders Hemochromatosis, Fragile X, Cystic Fibrosis, Factor V Leiden
  • Thrombophilia Panel
  • HFE(C282y-H63D)
  • Celiac
  • JakV617F
  • BRAFV600E
 Multi-Gene Disorders Dyslipidaemias  
 Oncology Solid Organ: Breast, colon, lungs, therapeutic response, prognostic testing
  • Myelofibrosis &  ET(Jak2/MPL/Cal)
  • HES (FIP1L1-PDGFRα)
  • Hairy Cell Leukemia 
  • Melanoma (BRAF) 
  • Colorectal cancers(KRAS/BRAF- NRAS)
  • Lung (KRAS/ALK/EGFR)
  • ALL translocation: (qualitative &quantitative) 
  • AML (translocations: (qualitative &quantitative)
  • Mantel Cell t(11;14)
  • Folicular Lymphoma t(14;18) 
  • Neuroblastoma (N-MYC Amplification)  
  • Sarcoma (Ewing & Rhabdomyo)  translocations
  • Synovial sarcoma (t(x;18))
  • CML (BCR-ABL: qualitative & quantitative) 
  • IgK & IgH gene rearrangement for clonality in Leukemia & Lymphoma
  • CLL (IgHV mutation)
 Pharmacogenetics CYP2D6, TPMT
  • DPYD,
  • ABL-Kinase,
  • CRC Panel,
  • CYP2D6,
  • TPMT
 Inherited Errors of metabolism glycogen storage disease, phenylketonuria, porphyria,  Lesch-Nyhan syndrome  
 Infectious Diseases  Sexually transmitted diseases, Respiratory diseases, Meningitis/Encephalitis, Hepatitis, Gastrointestinal diseases, Tropical diseases, Pediatric diseases, Drug resistance genes

ADV/ BK/ HSV/ EV/ RSV/ Corona/ Flu A & B/ JC/ MMR/ PIV/ B19/ Rota/ VZV/Bordetella Pertusis  & Para pertusis/Brucella/  C. Albicans/ ch. Pneu/  H. Influ/ E. Histo/ TB/ L.mono cytogenesis/ M.peunomonia/ S.aureus/M.genitalium/ N.meningitaisis/ N.gonorae/ P.carini /peunomoniae/aures/U.parvum &Urealiticum/ Trepanema palidum/ Ch.difficile/HCV genotyping (HBV-HCV-EBV- CMV-Toxo (quantitative& qualitative) )

Circulating cell free DNA Noninvasive prenatal testing, prognostic testing, therapeutic  response Future programme
Bioinformatics and Laboratory information systems Massively parallel sequencing data analysis, patient management algorithms, instrument interface Future programme
Education User education i.e. website, health care provider (example, nurse and doctor education), Laboratory and workflow design Involved in training of Hemato-oncology Fellow, and self training

 

JAPAN 

Dr. Yasunobu Yokoyama
Director
Reference Material Institute for Clinical Chemistry Standards
Omics Reference Laboratory
1-3-3, Azaminominami, Aoba-ku
Yokohama 225-0012
Japan
E-mail: y-yokoyama@reccs.net

Co-Applicant: Dr. Umemoto Hirohito
E-mail: h-umemoto@reccs.net

 

MDC Network Area of Interest

 

Examples

Specific Area

Single-Gene Disorders

Hemochromatosis, Fragile X, Cystic Fibrosis, Factor V Leide

 

Multi-Gene Disorders

Dyslipidaemias

 

Oncology

Solid Organ: Breast, colon, lungs, therapeutic response, prognostic testing

 Prognostic testing

  Hematological: Bcr-Abl quantitative PCR, B and T cell clonality  BCR-ABL 1 quantitative PCR
Pharmacogenetics CYP2D6, TPMT  
Inherited Errors of metabolism glycogen storage disease, phenylketonuria, porphyria,  Lesch-Nyhan syndrome   
Infectious Diseases  Sexually transmitted diseases, Respiratory diseases, Meningitis/Encephalitis, Hepatitis, Gastrointestinal diseases, Tropical diseases, Pediatric diseases, Drug resistance genes  
Circulating cell free DNA Noninvasive prenatal testing, prognosis testing, therapeutic response  Prognostic testing
Bioinformatics and Laboratory information systems Massively parallel sequencing data analysis, patient management algorithms, instrument interface  
Education User education i.e. website, health care provider (example, nurse and doctor education), Laboratory and workflow design  
Reference Materials  Calibrators, Certified reference materials, Low level materials  BCR-ABL1 Calibrators, Certified referencfe materials
Other Digital-PCR  

  

MEXICO 

Dr. Jessica Alejandra Rivera Domínguez
Carpermor
Genetics and Molecular Biology Department
Alfonso Herrera # 75
Co. San Rafael
Mexico City 06470
Mexico
Email: jessica.rivera@carpermor.com.mx
E-mail: jessicar0107@icloud.com

Co-Applicant:  Dr. Griselda Elvira López Ortega
Analytical Management Operation Department
E-mail: griselda.lopez@carpermor.com.mx

 

MDC Network Area of Interest

 

Examples

Specific Area

Single-Gene Disorders

Hemochromatosis, Fragile X, Cystic Fibrosis, Factor V Leiden

 

Multi-Gene Disorders

Dyslipidaemias

 
Oncology

Solid Organ: Breast, colon, lungs, therapeutic response, prognostic testing

 
 

Hematological: Bcr-Abl quantitative PCR, B and T cell clonality

 
Pharmacogenetics

CYP2D6, TPMT

 
Inherited Errors of metabolism

glycogen storage disease, phenylketonuria, porphyria,  Lesch-Nyhan syndrome

 
Infectious Diseases

Sexually transmitted diseases, Respiratory diseases, Meningitis/Encephalitis, Hepatitis, Gastrointestinal diseases, Tropical diseases, Pediatric diseases, Drug resistance genes

 
Circulating cell free DNA, Circulating Tumor Cells

Noninvasive prenatal testing, prognostic testing, therapeutic response

 
Bioinformatics and Laboratory information systems

Massively parallel sequencing data analysis, patient management algorithms, instrument interface

 
Education

User education i.e. website, health care provider (example, nurse and doctor education), Laboratory and workflow design

Laboratory and workflow design

 

THE NETHERLANDS 

Prof. Ron van Schaik
Laboratory Director
Dept. Clinical Chemistry
Erasmus University Medical Center
P.O. Box 2040
3000 CA Rotterdam
The Netherlands
E-mail: r.vanschaik@erasmusmc.nl 

  

MDC Network Area of Interest

 

Examples

Specific Area

Pharmacogenetics CYP2D6, TPMT

 

 

URUGUAY

Dr. Patricia Esperón
School of Chemistry “Universidad de la República”
Molecular Genetics Laboratory
Clinical Biochemistry Department
General Flores 2124
11800 Montevideo
Uruguay
E-mail: pesperon@fq.edu.uy; patricia.esperon@gmail.com

  

MDC Network Area of Interest

 

Examples

Specific Area

Single-Gene Disorders

Hemochromatosis, Fragile X, Cystic Fibrosis, Factor V Leiden

 Cystic fibrosis, Factor V Leiden, PAI, MTHFR, FII Familiar, hypercholesterolemia Huntington 

Multi-Gene Disorders

Dyslipidaemias

 

Oncology 

Solid Organ: Breast, colon, lungs, prognostic testing, therapeutic response

MSI colon cancer, Breast and colon cancer

 

Hematological: Bcr-Abl quantitative PCR, B and T cell clonality

 
Pharmacogenetics CYP2D6, TPMT  IL28, CYP2C9, VKOR1, CYP2C19, TPMT, UGT1A1
Inherited Errors of metabolism glycogen storage disease, phenylketonuria, porphyria,  Lesch-Nyhan syndrome MPS IV (GALNS and GLB1), galactosemia (GALT)
Infectious Diseases Sexually transmitted diseases, Respiratory diseases, Meningitis/Encephalitis, Hepatitis, Gastrointestinal diseases, Tropical diseases, Drug resistance, Pediatric diseases  
Circulating cell free DNA, Circulating Tumor Cells Noninvasive prenatal testing, prognosis testing, therapeutic response CTC detection and molecular analysis
Bioinformatics and Laboratory information systems Massively parallel sequencing data analysis, patient management algorithms, instrument interface Massively parallel sequencing data analysis, patient management algorithms 
Education User education i.e. website, health care provider (example, nurse and doctor education), Laboratory and workflow design Molecular Genetic education and laboratory training

 

USA

Dr. Deborah Payne PhD, DABCC, DABMM
Vice President
American Pathology Partners
Molecular Services
6116 East Warren Avenue
Denver, CO 80222
USA
E-mail: dpayne@unipathdx.com

Co-Applicant:  Dr. Jonathan Mancini
Director
E-mail: jmancini@unipathdx.com

   

MDC Network Area of Interest

 

Examples

Specific Area

Single-Gene Disorders

Hemochromatosis, Fragile X, Cystic Fibrosis, Factor V Leiden

 

Multi-Gene Disorders

Dyslipidaemias

 

Oncology 

Solid Organ: Breast, colon, lungs, therapeutic response, prognostic testing

Breast, lung, ovarian, prognostic & predictive testing; early detection

 

Hematological: Bcr-Abl quantitative PCR, B and T cell clonality

 
Pharmacogenetics CYP2D6, TPMT  
Inherited Errors of metabolism glycogen storage disease, phenylketonuria, porphyria,  Lesch-Nyhan syndrome  
Infectious Diseases Sexually transmitted diseases, Respiratory diseases, Meningitis/Encephalitis, Hepatitis, Gastrointestinal diseases, Tropical diseases, Drug resistance, Pediatric diseases  Human Papillomavirus
Circulating cell free DNA, Circulating Tumor Cells Noninvasive prenatal testing, prognosis testing, therapeutic response CTC detection and molecular analysis
Bioinformatics and Laboratory information systems Massively parallel sequencing data analysis, patient management algorithms, instrument interface  
Education User education i.e. website, health care provider (example, nurse and doctor education), Laboratory and workflow design  

 

Pending renewal:

SPAIN

Dr. Maria Isabel Tejada
Laboratorio de Genética Molecular
Servicio de Genética
Hospital Universitario Cruces
Pza. de Cruces s/n
48903-Barakaldo (Bizkaia)
Spain
E-mail: MARIAISABEL.TEJADAMINGUEZ@osakidetza.net  

  

MDC Network Area of Interest

 

Examples

Specific Area

Single-Gene Disorders

Hemochromatosis, Fragile X, Cystic Fibrosis, Factor V Leiden

 XLID (Fragile-X, included)

Oncology  Solid Organ: Breast, colon, lungs, therapeutic response, prognostic testing

 Hereditary Breast cancer

 

UK

Dr. Colin Graham
Regional Genetics Laboratories
Regional Lipid Clinic
Belfast Health and Social Care Trust
Belfast City Hospital
Lisburn Rd.
Belfast  BT97AB - UK
E-mail:  colin.graham@belfasttrust.hscni.net  

 

MDC Network Area of Interest

 

 Examples

Specific Area

Multi-Gene Disorders Dyslipidaemias 

 

 
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