Advancing excellence in laboratory medicine for better healthcare worldwide

Molecular Diagnostic Centres of the IFCC

Click here to download the MDC Document: Process for review of applications and selection of Molecular Diagnostic Centers  

Click here to download the " Molecular Diagnostics Centers Network APPLICATION FORM" and the " Molecular Diagnostics Expert APPLICATION FORM"

 

About the Molecular Diagnostic Centres (MDC) Project of IFCC C-MD

The MDC network is a new concept which is about to get underway and a call for applications will soon be made through the various member societies of the IFCC. Additional details concerning participation, application forms, and fields of application, or areas of interest, are detailed further below.

Each MDC which is formed will represent an interface between the IFCC C-MD and clinical laboratories performing molecular diagnostic tests. The MDC concept was formulated to promote formation of an international network of molecular diagnostic laboratories and to encourage close collaboration within this network. This approach supports the IFCC-CMD's broader initiatives for excellence and international collaborations in molecular diagnostics. 

 

Terms of reference of the MDCs

  • To provide a point of contact to Molecular Diagnostic Laboratories in the analysis and/or interpretation of complex analytical/clinical scenarios.
  • To participate in international studies involving the evaluation of new methodological approaches. 


MDC fields of application and joining a MDC Network

Individuals and organizations can apply to join an MDC network by completion of an application form. There are two levels of participation, including participation as an IFCC MDC Network Member or as an IFCC MDC Expert Laboratory. IFCC MDC Network Members will be given access to the MDC listserver for their area of interest. IFCC MDC Expert Laboratories will be engaged at a higher level and act as a point of reference within a special area of interest within the IFCC MDC Network. Further details are available on the application form.

The fields of application which will be supported depends in part on the interest shown in any particular field or area of interest and the expertise of the applicants. Shown below are a number of examples. Applicants may nominate other fields not covered by the list below in the application form. The C-MD is happy to consider other fields depending on the level of interest. 

Examples of fields of application

  • cystic fibrosis,
  • haemochromatosis
  • dyslipidaemias Fragile X
  • pharmacogenetics

Examples of molecular oncology fields of application

  • breast cancer
  • melanoma
  • gene amplification circulating tumour cells
  • laser microdissection
  • acquired rearrangements

 

MDC Application Form

Applications for membership of the IFCC C-MD's MDC network is through submission of an application form. A Word version of the application form can be downloaded from the following link: MDC Application Form

 

Molecular Diagnostic Centers Network 

 

AUSTRIA 


Dr. Zeillinger Robert


Molecular Oncology Group
Department of Obstetrics and Gynecology
Medical University of Vienna
Waehringer Guertel 18-20, 5Q
A-1090 Vienna
Austria
e-mail: robert.zeillinger@meduniwien.ac.at; r.zeillinger@oncolab.at
Dr. Obermayr Eva
email: Eva.obermayr@meduniwien.ac.at

 

MDC Network Area of Interest

 

Examples

Specific Area

Oncology

Solid Organ: Breast, colon, lungs, therapeutic response, prognostic testing

Breast, lung, ovarian, prognostic & predictive testing; early detection

 

Circulating Tumor Cells, Circulating cell free DNA

CTC detection and molecular analysis

 

CANADA

Prof. Dr. Yves Giguére PhD, FRCPC


CHU de Québec – Université Laval
Service de biochimie médicale
Département de biologie médicale
10, rue de l’Espinay
Québec, QC - G1L 3L5
Canada
Email: Yves.Giguere@crchudequebec.ulaval.ca
Prof. Dr. François Rousseau MSc, FRCPC, FCAHS
email: Francois.rousseau@fmed.ulaval.ca

 

MDC Network Area of Interest

 

Examples

Specific Area

Single-Gene Disorders

Hemochromatosis, Fragile X, Cystic Fibrosis, Factor V Leiden

Fragile X, Fragile E, Hemochromatosis, Cystic Fibrosis, Tyrosinemia, ACCPN

Multi-Gene Disorders

Dyslipidemias

Dyslipidemias

Circulating cell free DNA, Circulating Tumor Cells

Noninvasive prenatal testing, prognostic testing, therapeutic response

NIPT

Bioinformatics and Laboratory information systems

Massively parallel sequencing data analysis, patient management algorithms, instrument interfacing

NGS data analys

 

CANADA 

Dr. Lianna Kyriakopoulou


Hospital for Sick Children
Department of Paediatric Laboratory Medicine
Division of Genome Diagnostics
555 University Avenue
Toronto, Ontario M5G 1X8
Canada
e-mail: Lianna.kyriakopoulou@sickkids.ca; Lianna.kyriakopoulou@utoronto.ca
Dr. Peter Ray
e-mail: peter.ray@sickkids.ca

 

MDC Network Area of Interest

 

Examples

Specific Area

Single-Gene Disorders

Hemochromatosis, Fragile X, Cystic Fibrosis, Factor V Leiden

CF, FRX Beckwith-Wiedeman, Angelman, achndroplasia, 22q11.2 deletion, DMD, dopamine beta-hydroxylase, cherubism, CHARGE, Caffey, BOR syndrome, BMT, X-chromosome inactivation, thanatophoric dysplasia, Trismus-pseudocamptomegaly, SMA, SMB, Simpson Golabi, SBDS, Russel Silver, retinoblastoma, Prader Willi, DFN3/4, Li-Fraumeni, Hunter,

Multi-Gene Disorders

Dyslipidemias

Noonan, Neurofibromatosis, HLH MAS, arrhythmic right venricular cardiomyopathy, connective tissue, craniosynostosis, congenital muscular dystrophies, complement based renal disease, NCL, mitochondrial hearing loss, hereditary spastic paraplegia, hereditary hemorrhagic telangiectasia, USHER, Stickler, hereditary hearing loss (9 genes), non-syndromic hearing loss, focal segmental glomerulosclerosis

Inherited Errors of metabolism

glycogen storage disease, phenylketonuria, porphyria, Lesch-Nyhan syndrome

Hunter, Fabry, Gaucher, CLN, mitochondrial hearing loss, (WES) exome sequencing

 

 

FRANCE 


Dr. Emmanuelle DeRaucourt

eAPHP, HUPNVS, Beaujon
Hématologie Biologique
100, bd du Général Leclerc
92118 Clichy Cédex
France
e-mail: emmanuelle.de-raucourt@aphp.fr
Dr. Katell Peoc’h
e-mail: katell.peoch@aphp.fr

 

MDC Network Area of Interest

 

Examples

Specific Area

Single-Gene Disorders

Hemochromatosis, Fragile X, Cystic Fibrosis, Factor V Leiden

Hemostasis disorders

 

Hematological: Bcr-Abl quantitative PCR, B and T cell clonality

Jak2 mutations

Education

User education i.e. website, health care provider (example, nurse and doctor education), Laboratory and workflow design

X (Anticoagulants clinic)

 

GERMANY

Prof. Beniamin Ghebremedhin


Institute for Med. Laboratory Diagnostics
HELIOS Klinikum Wuppertal
Witten Herdecke University
Heusnerstr. 40
42283 Wuppertal
Germany
email: beniam.ghebremedhin@helios-kliniken.de
Prof. Dr. med. Parviz Ahmad-Nejad
Email: parviz.ahmad-nejad@helios-kliniken.de

 

MDC Network Area of Interest

 

Examples

Specific Area

 Infectious Diseases

Sexually transmitted diseases, Respiratory, Meningitis/Encephalitis, Hepatitis, Gastrointestinal Diseases, Tropical Diseases, Drug resistance, Pediatric Diseases

Infectious Diseases - Drugresistance- MRSA/Carbapenemases/ESBL- VRE VanA&B

 

Other(s) (specify): Infectious Diseases - Drug resistance- MRSA/Carbapenemases/ESBL- VRE VanA&B

 

 

  

GERMANY

Prof. Dr. med. Michael Neumaier


Institute for Clinical Chemistry
Medical Faculty Mannheim of the University of Heidelberg
University Hospital Mannheim
Theodor-Kutzer-Ufer 1-3
68167 Mannheim
Germany
Email: michael.neumaier@medma.uni-heidelberg.de

 

MDC Network Area of Interest

 

Examples

Specific Area

Single-Gene Disorders

Hemochromatosis, Fragile X, Cystic Fibrosis, Factor V Leiden

Hemocromatosis, Thrombophilia

Oncology

Solid Organ: Breast, colon, lungs, therapeutic response, prognostic testing

Molecular Oncology
Pharmacogenetics

CYP2D6, TPMT

 

HONG KONG

Dr. Chan, On Kei Angel


Division of Clinical Biochemistry
Department of Pathology & Clinical Biochemistry
LG1, Block K
Queen Mary Hospital
102 Pokfulam Road
Hong Kong
e-mail: cok436@ha.org.hk; sch121@ha.org.hk
Mr. Chung Him See
e-mail: sch121@ha.org.hk

 

MDC Network Area of Interest

 

Examples

Specific Area

Single-Gene Disorders

Hemochromatosis, Fragile X, Cystic Fibrosis, Factor V Leiden

Neurological disorders, congenital myopathies, mitochondrial diseases, inherited endocrinopathies, disorders of sex development

Inherited Errors of metabolism

glycogen storage disease, phenylketonuria, porphyria,  Lesch-Nyhan syndrome

Congenital adrenal hyperplasia, steroid metabolic diseases, amino acid disorders, organic acid disorders

 

IRAN

Dr. Poopak, Behzad
Payvand Clinical and Specialty Laboratory
Unit 4, No 174, Zafar St.
Shariati Ave.
Tehran
Iran
e-mail: bpoopak@gmail.com; info@payvandlab.com.com
Dr. Masoumeh Rajabi
e-mail: masoumeh_rajabibazl@yahoo.com

 

MDC Network Area of Interest

 

Examples

Specific Area

Single-Gene Disorders

Hemochromatosis, Fragile X, Cystic Fibrosis, Factor V Leiden

Thrombophilia Panel; HFE(C282y-H63D); Celiac; JakV617F; BRAFV600E

Oncology

Solid Organ: Breast, colon, lungs, therapeutic response, prognostic testing

Myelofibrosis & ET(Jak2/MPL/Cal); HES (FIP1L1-PDGFRα ); Hairy Cell Leukemia;  Melanoma (BRAF); Colorectal cancers(KRAS/BRAF- NRAS); Lung (KRAS/ALK/EGFR); ALL translocation: (qualitative &quantitative); AML (translocations: (qualitative &quantitative); Mantel Cell t(11;14); Folicular Lymphoma t(14;18); Neuroblastoma (N-MYC Amplification); Sarcoma (Ewing & Rhabdomyo) translocations; Synovial sarcoma (t(x;18))

 

Hematological: Bcr-Abl quantitative PCR, B and T cell clonality

CML (BCR-ABL: qualitative & quantitative); IgK & IgH gene rearrangement for clonality in Leukemia & Lymphoma; CLL (IgHV mutation)

 

Circulating Tumor Cells, Circulating cell free DNA

On developing

Pharmacogenetics

CYP2D6, TPMT

DPYD; ABL-Kinase; CRC Panel; CYP2D6; TPMT

Infectious Diseases

Sexually transmitted diseases, Respiratory diseases, Meningitis/Encephalitis, Hepatitis, Gastrointestinal diseases, Tropical diseases, Pediatric diseases, Drug resistance genes

ADV/ BK/ HSV/ EV/ RSV/ Corona/; Flu A & B/ JC/ MMR/ PIV/ B19/ Rota/ VZV/; Bordetella Pertusis  & Para pertusis/; Brucella/  C. Albicans/ ch. Pneu/  H. Influ/ E. Histo/ TB/ L.mono cytogenesis/ M.peunomonia/ S.aureus/; M.genitalium/ N.meningitaisis/ N.gonorae/ P.carini /;S. peunomoniae/; S. aures/; U.parvum &Urealiticum/ Trepanema palidum/ Ch.difficile/; HCV genotyping; (HBV-HCV-EBV- CMV-Toxo (quantitative& qualitative) 

Circulating cell free DNA

Circulating cell free DNA, Massively parallel sequencing data analysis for cell free DNA, Noninvasive prenatal testing

Future program

Bioinformatics and Laboratory information systems

Massively parallel sequencing data analysis, patient management algorithms, instrument interface

Future program

External Quality Assessment

Proficiency testing, alternate assessment (specimen exchange)

EQAP/ Inter Lab double checking

Reference Materials

Calibrators, Certified reference materials, Low level materials

All controls & for quantitative BCR-ABL; calibrator

All controls & for quantitative BCR-ABL; calibrator

Education

User education i.e. website, health care provider (example, nurse and doctor education), Laboratory and workflow design

Involved in training of Hemato-oncology Fellow, and self training

Involved in training of Hemato-oncology Fellow, and self training

 

JAPAN

Dr. Yokoyama Yasunobu

Reference Material Institute for Clinical Chemistry Standards
Department: Omics Reference Laboratory
1-3-3, Azaminominami, Aoba-ku
Yokohama 225-0012, Japan
Email: y-yokoyama@reccs.net
Dr. Umemoto Hirohito
email: h-umemoto@reccs.net

 

MDC Network Area of Interest

 

Examples

Specific Area

Oncolocy

Solid organ: Breast, colon, lungs, prognostic testing, therapeutic response

prognostic testing

 

Hematological: Bcr-Abl quantitative PCR, B and T cell clonality, etc.

BCR-ABL1 quantitative PCR

Circulating cell free DNA, Circulating Tumor Cells

Noninvasive prenatal testing, prognostic testing, therapeutic response

Prognostic testing

Reference Materials 

 

BCR-ABL1 Calibrators, Certified reference materials

 

 

MEXICO 

Dr. Jessica Alejandra Rivera Domínguez

Head of Genomics and Molecular Biology Carpemor
Genomics and Molecular Biology
Alfonso Herrera # 75 Col. San Rafael
Mexico City 06470
Mexico
e-mail: jessica.rivera@carpermor.com.mx; jessicar0107@icloud.com;
Dr. Griselda Elvira López Ortega
e-mail: griselda.lopez@carpermor.com.mx

 

MDC Network Area of Interest

 

Examples

Specific Area

Single-Gene Disorders

Hemochromatosis, Fragile X, Cystic Fibrosis, Factor V Leiden

X

Oncology

Solid Organ: Breast, colon, lungs, therapeutic response, prognostic testing

X

 

Hematological: Bcr-Abl quantitative PCR, B and T cell clonality

X

Pharmacogenetics

CYP2D6, TPMT

X

Infectious Diseases

Sexually transmitted diseases, Respiratory diseases, Meningitis/Encephalitis, Hepatitis, Gastrointestinal diseases, Tropical diseases, Pediatric diseases, Drug resistance genes

X

Circulating cell free DNA

Circulating cell free DNA, Massively parallel sequencing data analysis for cell free DNA, Noninvasive prenatal testing

X

Bioinformatics and Laboratory information systems

Massively parallel sequencing data analysis, patient management algorithms, instrument interface

X

External Quality Assessment

Proficiency testing, alternate assessment (specimen exchange)

X

Reference Materials

Calibrators, Certified reference materials, Low level materials

X

Education

User education i.e. website, health care provider (example, nurse and doctor education), Laboratory and workflow design

X

 

THE NETHERLANDS

Dr. Ron Van Schaik 

Dept. Clinical Chemistry
Erasmus University Medical Center
P.O. Box 2040
3000 CA Rotterdam
The Netherlands
email r.vanschaik@erasmusmc.nl

 

MDC Network Area of Interest

 

Examples

Specific Area

 Pharmacogenetics

CYP2D6, TPMT

 

 

PARAGUAY

Dr. Graciela Russomando

Molecular Biology and Biotechnology Department
Instituto de Investigaciones en Ciencias de la Salud
Universidad Nacional de Asunción
Campus Universitario
Dr Cecilio Baez c/ Dr Gaspar Villamayor
San Lorenzo, PoBox 2160
Paraguay
e-mail: grusso@rieder.net.py; graciela.russomando@gmail.com

 

MDC Network Area of Interest

 

Examples

Specific Area

Oncology

Solid Organ: Breast, colon, lungs, therapeutic response, prognostic testing

Breast, colon, lungs, therapeutic response, prognostic testing

 

Circulating Tumor Cells, Circulating cell free DNA

Circulating Tumor Cells, Circulating cell free DNA

Infectious Diseases

Sexually transmitted diseases, Respiratory diseases, Meningitis/Encephalitis, Hepatitis, Gastrointestinal diseases, Tropical diseases, Pediatric diseases, Drug resistance genes

Children and adults health. , Respiratory diseases, Meningitis/Encephalitis, Gastrointestinal diseases, Tropical diseases, Drug resistance genes

 

  

SPAIN

Dr. Maria Isabel Tejada

Laboratorio de Genética Molecular
Servicio de Genética
Hospital Universitario Cruces
Pza. de Cruces s/n
48903-Barakaldo (Bizkaia)
Spain
Email: MARIAISABEL.TEJADAMINGUEZ@osakidetza.net

  

MDC Network Area of Interest

 

Examples

Specific Area

Single-Gene Disorders

Hemochromatosis, Fragile X, Cystic Fibrosis, Factor V Leide

XLID (Fragile-X included)

Oncology

Solid Organ: Breast, colon, lungs, therapeutic response, prognostic testing

Hereditary Breast Cancer

 

 

TURKEY 

Dr. Mine Guzel

Biruni Genetic Diseases Diagnostic Center
Gursel Mahallesi Kagithane Caddesi No:14/1
Kagithane
Istanbul
Turkey
e-mail: mguzel@biruni.com.tr; rakcaytan@biruni.com.tr;
Dr. Remin Akcay Tan
e-mail: rakcaytan@biruni.com.tr

  

MDC Network Area of Interest

 

Examples

Specific Area

Single-Gene Disorders

Hemochromatosis, Fragile X, Cystic Fibrosis, Factor V Leiden

X

Oncology

Solid Organ: Breast, colon, lungs, therapeutic response, prognostic testing

X

 

Hematological: Bcr-Abl quantitative PCR, B and T cell clonality

X

Pharmacogenetics

CYP2D6, TPMT

X

Infectious Diseases

Sexually transmitted diseases, Respiratory diseases, Meningitis/Encephalitis, Hepatitis, Gastrointestinal diseases, Tropical diseases, Pediatric diseases, Drug resistance genes

X

Circulating cell free DNA

Circulating cell free DNA, Massively parallel sequencing data analysis for cell free DNA, Noninvasive prenatal testing

X

 

 

UK

Dr. Colin Graham

Regional Genetics Laboratories
(co-applicant: Regional Lipid Clinic)
Belfast Health and Social Care Trust
Belfast City Hospital
Lisburn Rd.
Belfast  BT97AB - UK
Email:  colin.graham@belfasttrust.hscni.net

 

 

MDC Network Area of Interest

 

Examples

Specific Area 

Multi-Gene Disorders

Dyslipidaemias

 

URUGUAY


Dr. Patricia Esperón

Associate Professor
Head of Molecular Genetics Laboratory
Facultad de Químíca
Universidad de la República
Clinical Biochemistry
General Flores 2124
11800 Montevideo
Uruguay
e-mail: pesperon@fq.edu.uy; patricia.esperon@gmail.com;
Dr. Vital Marcelo

 

MDC Network Area of Interest

 

Examples

Specific Area

Single-Gene Disorders

Hemochromatosis, Fragile X, Cystic Fibrosis, Factor V Leiden

Cystic Fibrosis, Factor V Leiden, PAI, MTHFR, FII

Familial hypercholesterolemia

Huntington

Oncology

Solid Organ: Breast, colon, lungs, prognostic testing, therapeutic response

MSI colon cancer

Breast  and colon cancer

Pharmacogenetics

CYP2D6, TPMT

IL28, CYP2C9, VKOR1,CYP2C19, TPMT,UGT1A1

Inherited Errors of metabolism

glycogen storage disease, phenylketonuria, porphyria,  Lesch-Nyhan syndrome

MPS IV(GALNS and GLB1), galactosemia (GALT)

Circulating cell free DNA, Circulating Tumor Cells

Noninvasive prenatal testing, prognostic testing, therapeutic response

Noninvasive prenatal testing, prognostic testing, therapeutic response

Bioinformatics and Laboratory information systems

Massively parallel sequencing data analysis, patient management algorithms, instrument interfacing

Massively parallel sequencing data analysis, patient management algorithms

Education

User education i.e. website, health care provider (example, nurse and doctor education), Laboratory and workflow design

Molecular Genetic education and laboratory training

 

 

USA

Dr. Deborah Payne


Molecular Services
UniPath-American Pathology Partners
Denver, CO 80222
USA
e-mail: Debs_payne@yahoo.com; dpayne@ap2.com
Mr. Jonathan Mancini
e-mail: jmancini@unipathdx.com  

  

MDC Network Area of Interest

 

Examples

Specific Area

Infectious Diseases

Sexually transmitted diseases, Respiratory diseases, Meningitis/Encephalitis, Hepatitis, Gastrointestinal diseases, Tropical diseases, Pediatric diseases, Drug resistance genes

Human Papillomavirus

 

 

 

 

 

 

 

 
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