Advancing excellence in laboratory medicine for better healthcare worldwide

Standardization of Thyroid Function Tests (C-STFT)

Membership

Name Position Country Term Time in Office
L. Thienpont Chair BE 2nd 2015 01 - 2017 12
B. Das Member IN 2nd 2015 01 - 2017 12
J.D. Faix Member US 2nd 2015 01 - 2017 12
F. MacKenzie Member UK 2nd 2015 01 - 2017 12
M.M. Patru  Member/OCD US 1st 2015 07 - 2017-12
F. Quinn Consultant US    
M. Rottmann  Consultant DE    
K. Van Uytfanghe Consultant BE

Terms of Reference

  • Develop reference measurement systems (reference materials/reference methods) to establish traceability of free thyroid hormone and TSH assays.
  • Establish a network of laboratories competent to offer reference measurement services for free thyroid hormones.
  • Provide an infrastructure for procurement of serum panels.
  • Demonstrate that the traceable assays can use a common reference interval; use this as a basis for further elaboration of the reference intervals by the IVD manufacturers; consult with clinicians about the need for ethnic, age- or sub-population-specific reference intervals in co-operation with C-RIDL.
  • Liaise with key stakeholders to implement the use of the traceable assays in routine clinical practice.
  • Through collaboration with IFCC EMD, provide educational materials for manufacturers, clinicians and patients which will support the implementation of traceable assays.  

Current Projects

  • Recalibration of FT4 and TSH assays after the Phase IV method comparison studies on clinically relevant samples: is intended as technical standardization/harmonization process, by which FT4 assays will become traceable to the conventional reference measurement procedure based on equilibrium dialysis (ED) isotope dilution-liquid chromatography-/tandem mass spectrometry (ID-LC/MS/MS), TSH assays to the statistically inferred all-procedure trimmed mean (APTM).
  • Measure a FT4 and TSH panel of each 120 American apparently healthy volunteers with the recalibrated assays; measure the FT4 panel also with the conventional reference measurement procedure; use the data as proof-of-concept for standardization of FT4 and harmonization of TSH by demonstrating that the traceable assays can use a common reference interval; use this as a basis for further elaboration of the reference intervals by the IVD manufacturers.
  • Get into contact with all involved stakeholders for benefit-risk analysis in preparation of the implementation of the standardized/harmonized assays. 
  • Promotion of the concept of Traceability in Latin America

Resources

Resources made available by the C-STFT are available here

 

Read more at: http://www.ifcc-cstft.org 

 

List of Corresponding Members, nominated by National Societies

Name Full and Affiliate Member Societies
Paul Williams Australasian Assocition of Clinical Biochemists (AACB)
Pierre Carayon Société Française de Biologie Clinique (SFBC)
M. Reza Bakhtiari Iranian Association of Clinical Laboratory Doctors
Akira Hishinuma Japan Society of Clinical Chemistry (JSCC)
Simeon Adebisi Association of Clinical Chemists Nigeria (ACCN)
Jens Berg

Norwegian Society of Medical Biochemistry

Lakminda Thilakarathna Association for Clinical Biochemistry, Sri Lanka
Sevgi Eskiocak  Turkish Biochemical Society (TBS)
David Halsall Association for Clinical Biochemistry (ACB) - UK

 

List of Corresponding Members, nominated by Corporate Members

Name Corporate Member
Gordon Avery ABBOTT Diagnostics
Annette Adelmann BECKMAN COULTER
Paul Sibley SIEMENS

Committee Chair's contact

Prof. Linda THIENPONT
Faculty of Pharmaceutical Sciences
Ghent University
Ottergemsesteenweg 460
B-9000 GENT
BELGIUM
Tel: +32 9 264 8104
Fax: +32 9 264 8198
E-mail: Linda.Thienpont@ugent.be

 
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